Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 3638592..3639304 Replicon chromosome
Accession NZ_CP025317
Organism Escherichia albertii strain 1551-2

Toxin (Protein)


Gene name higB Uniprot ID A0A8D9ULK1
Locus tag CXP54_RS18615 Protein ID WP_059257620.1
Coordinates 3638592..3638894 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CXP54_RS18620 Protein ID WP_000806446.1
Coordinates 3638966..3639304 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP54_RS18590 3635255..3636097 + 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
CXP54_RS18595 3636169..3637521 + 1353 WP_059225142.1 glutathione-disulfide reductase -
CXP54_RS18600 3637575..3637658 - 84 WP_001295215.1 hypothetical protein -
CXP54_RS18605 3637686..3637859 + 174 WP_000553433.1 hypothetical protein -
CXP54_RS18610 3637949..3638428 - 480 WP_103054024.1 hypothetical protein -
CXP54_RS18615 3638592..3638894 + 303 WP_059257620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CXP54_RS18620 3638966..3639304 + 339 WP_000806446.1 HigA family addiction module antidote protein Antitoxin
CXP54_RS24390 3639395..3639532 + 138 WP_199768253.1 hypothetical protein -
CXP54_RS18625 3639879..3640445 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
CXP54_RS18635 3640592..3641122 + 531 WP_000480294.1 LuxR family transcriptional regulator -
CXP54_RS18640 3641194..3642222 - 1029 WP_103054025.1 hematinate-forming heme oxygenase ChuS -
CXP54_RS18645 3642271..3644253 - 1983 WP_103054026.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11843.53 Da        Isoelectric Point: 9.8664

>T90070 WP_059257620.1 NZ_CP025317:3638592-3638894 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWANGKAEDLYLDPHKY

Download         Length: 303 bp

>T90070 NZ_CP025317:3638592-3638894 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAACGCCGCAACTACCTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGCTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT90070 WP_000806446.1 NZ_CP025317:3638966-3639304 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp

>AT90070 NZ_CP025317:3638966-3639304 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References