Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2970806..2971457 Replicon chromosome
Accession NZ_CP025317
Organism Escherichia albertii strain 1551-2

Toxin (Protein)


Gene name cptA Uniprot ID A0A8D9PM36
Locus tag CXP54_RS15000 Protein ID WP_044714929.1
Coordinates 2970806..2971210 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CXP54_RS15005 Protein ID WP_000354046.1
Coordinates 2971191..2971457 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CXP54_RS14980 2966764..2968497 - 1734 WP_000813238.1 single-stranded-DNA-specific exonuclease RecJ -
CXP54_RS14985 2968503..2969213 - 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CXP54_RS14990 2969238..2970134 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CXP54_RS14995 2970246..2970767 + 522 WP_103053870.1 flavodoxin FldB -
CXP54_RS15000 2970806..2971210 - 405 WP_044714929.1 protein YgfX Toxin
CXP54_RS15005 2971191..2971457 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CXP54_RS24235 2971447..2971677 - 231 WP_000181267.1 hypothetical protein -
CXP54_RS15010 2971709..2972689 + 981 WP_103053871.1 tRNA-modifying protein YgfZ -
CXP54_RS15015 2973129..2973788 - 660 WP_000250281.1 hemolysin III family protein -
CXP54_RS15020 2973956..2974267 - 312 WP_001182937.1 N(4)-acetylcytidine aminohydrolase -
CXP54_RS15025 2974312..2975745 + 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15835.76 Da        Isoelectric Point: 10.2082

>T90066 WP_044714929.1 NZ_CP025317:c2971210-2970806 [Escherichia albertii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLCLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T90066 NZ_CP025317:c2971210-2970806 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGTGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT90066 WP_000354046.1 NZ_CP025317:c2971457-2971191 [Escherichia albertii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT90066 NZ_CP025317:c2971457-2971191 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References