Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 1911692..1912292 Replicon chromosome
Accession NZ_CP025086
Organism Methylovirgula ligni strain BW863

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag CWB41_RS09165 Protein ID WP_115836997.1
Coordinates 1911999..1912292 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CWB41_RS09160 Protein ID WP_115836998.1
Coordinates 1911692..1911997 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWB41_RS09135 1906857..1907399 + 543 WP_115837002.1 transcription elongation factor GreB -
CWB41_RS16280 1907452..1907961 - 510 WP_115837001.1 hypothetical protein -
CWB41_RS09145 1908147..1909763 - 1617 WP_115837000.1 fumarate hydratase -
CWB41_RS09150 1909866..1910762 - 897 WP_181902973.1 tRNA glutamyl-Q(34) synthetase GluQRS -
CWB41_RS09155 1910949..1911644 + 696 WP_115836999.1 prolyl oligopeptidase family serine peptidase -
CWB41_RS09160 1911692..1911997 - 306 WP_115836998.1 putative addiction module antidote protein Antitoxin
CWB41_RS09165 1911999..1912292 - 294 WP_115836997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWB41_RS09170 1912346..1913086 - 741 WP_115836996.1 methyltransferase domain-containing protein -
CWB41_RS09175 1913191..1913961 + 771 WP_115836995.1 hydroxyacylglutathione hydrolase -
CWB41_RS09180 1914072..1915790 + 1719 WP_115836994.1 bifunctional diguanylate cyclase/phosphodiesterase -
CWB41_RS09185 1915804..1916409 - 606 WP_115836993.1 polyhydroxyalkanoate synthesis repressor PhaR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10829.36 Da        Isoelectric Point: 9.4235

>T89780 WP_115836997.1 NZ_CP025086:c1912292-1911999 [Methylovirgula ligni]
MEIRQTETYSDWFDSLKDQRAKARIAIRIRRLSLGNPGDVKPVGHGISELRISYGPGYRVYYVQRGLVFVVLLCGGDKSS
QAADIGKAKELASQLED

Download         Length: 294 bp

>T89780 NZ_CP025086:c1912292-1911999 [Methylovirgula ligni]
ATGGAAATTCGGCAAACCGAGACCTACTCAGACTGGTTCGATTCGCTGAAGGATCAGCGCGCCAAAGCCCGGATCGCCAT
TCGCATTCGCCGATTGTCACTGGGAAATCCGGGTGATGTGAAGCCGGTGGGCCATGGCATCAGCGAACTCAGGATTTCTT
ATGGTCCAGGTTACCGGGTTTATTACGTTCAACGCGGCCTGGTGTTTGTTGTTTTGCTCTGCGGCGGCGACAAAAGCTCA
CAAGCCGCTGATATTGGAAAAGCCAAGGAGCTGGCATCGCAGCTAGAGGACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10875.11 Da        Isoelectric Point: 4.4280

>AT89780 WP_115836998.1 NZ_CP025086:c1911997-1911692 [Methylovirgula ligni]
MSLKTRPWDASEHLDSSQAIAEYLEAAFEDGDPQVISAALGDVARARGMTELSRETGLSRESLYRALSPDGHPEFSTVVK
VLNAFGVRLEAKPVGSEIEAA

Download         Length: 306 bp

>AT89780 NZ_CP025086:c1911997-1911692 [Methylovirgula ligni]
ATGTCACTTAAAACACGCCCATGGGACGCTTCCGAACACCTCGATTCCTCTCAGGCGATCGCGGAATATCTTGAGGCCGC
ATTCGAGGATGGTGATCCGCAGGTTATTTCTGCTGCGCTCGGGGATGTGGCTCGGGCTCGGGGGATGACAGAACTCTCAC
GGGAAACTGGGCTCTCCAGAGAGAGTCTCTATCGTGCGCTCTCCCCCGACGGACACCCCGAGTTCAGCACCGTCGTCAAG
GTTCTCAATGCGTTTGGCGTTCGTCTTGAAGCCAAGCCTGTCGGAAGCGAGATCGAGGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References