Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4672699..4673332 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CWC46_RS21325 Protein ID WP_037380606.1
Coordinates 4673009..4673332 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CWC46_RS21320 Protein ID WP_021014517.1
Coordinates 4672699..4673016 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS21305 4667868..4669799 - 1932 WP_021014520.1 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (decyclizing) -
CWC46_RS21310 4669855..4671366 - 1512 WP_021014519.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
CWC46_RS21315 4671685..4672545 + 861 WP_021014518.1 MurR/RpiR family transcriptional regulator -
CWC46_RS21320 4672699..4673016 - 318 WP_021014517.1 helix-turn-helix domain-containing protein Antitoxin
CWC46_RS21325 4673009..4673332 - 324 WP_037380606.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWC46_RS21330 4673785..4674882 + 1098 WP_021014516.1 D-alanine--D-alanine ligase -
CWC46_RS21335 4675130..4675884 + 755 Protein_4122 hypothetical protein -
CWC46_RS23125 4675864..4676338 + 475 Protein_4123 transposase -
CWC46_RS21340 4676730..4677650 - 921 WP_021014514.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-91)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11971.80 Da        Isoelectric Point: 5.7259

>T89778 WP_037380606.1 NZ_CP025085:c4673332-4673009 [Serratia sp. ATCC 39006]
MCKAAKAILSGLPGDHLGKYTYKKRLALPAVSPQGGARSIVFFNNGTHVYFFDMYLKSGLSKKKGKELEDDEIDAYCKIA
PDFIALTVEQIQQLLEDRELIEVNCDE

Download         Length: 324 bp

>T89778 NZ_CP025085:c4673332-4673009 [Serratia sp. ATCC 39006]
TTGTGCAAAGCAGCCAAGGCCATACTTTCAGGTCTTCCCGGTGATCATTTAGGGAAGTACACGTACAAAAAACGCCTTGC
TTTGCCAGCAGTGAGTCCACAAGGCGGCGCACGCTCGATAGTGTTTTTCAACAACGGAACACATGTTTACTTCTTTGATA
TGTACCTGAAAAGTGGGTTATCAAAGAAGAAAGGAAAAGAGCTGGAAGACGATGAAATTGACGCGTATTGCAAGATCGCA
CCTGATTTCATCGCCCTGACGGTAGAGCAGATACAGCAGCTGTTGGAAGATAGAGAACTGATAGAGGTAAATTGTGATGA
GTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11861.91 Da        Isoelectric Point: 10.8200

>AT89778 WP_021014517.1 NZ_CP025085:c4673016-4672699 [Serratia sp. ATCC 39006]
MSDRLKRIQGMAQRYNKLGVVKDETVAAINAAVDARNIPKVRAMTGKQIKEVRVRYKMSQSALARMIGMSVESVSKWERD
ESKPNQAALRIINVIEEKGPEVFMV

Download         Length: 318 bp

>AT89778 NZ_CP025085:c4673016-4672699 [Serratia sp. ATCC 39006]
ATGAGTGATCGTCTGAAACGCATTCAAGGTATGGCTCAGCGCTATAACAAATTGGGCGTAGTTAAAGATGAGACAGTCGC
CGCCATTAATGCTGCGGTTGATGCGCGCAACATTCCGAAGGTTCGCGCCATGACGGGCAAACAGATTAAGGAAGTACGCG
TGCGTTATAAAATGTCTCAGTCGGCGCTTGCTCGCATGATAGGCATGTCAGTTGAGAGCGTGTCGAAGTGGGAGCGTGAT
GAGAGCAAACCAAATCAGGCAGCGCTACGCATCATCAATGTTATTGAAGAAAAAGGACCAGAAGTTTTCATGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References