Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4446809..4447335 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2I5TNW0
Locus tag CWC46_RS20300 Protein ID WP_021014717.1
Coordinates 4447030..4447335 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2I5TNW4
Locus tag CWC46_RS20295 Protein ID WP_021014718.1
Coordinates 4446809..4447027 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS20270 4443194..4444081 + 888 WP_021014723.1 LysR family transcriptional regulator -
CWC46_RS20275 4444232..4445230 - 999 Protein_3913 Fic family protein -
CWC46_RS20285 4445315..4446334 + 1020 WP_021014721.1 IS630 family transposase -
CWC46_RS22955 4446562..4446810 - 249 WP_037380644.1 hypothetical protein -
CWC46_RS20295 4446809..4447027 + 219 WP_021014718.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
CWC46_RS20300 4447030..4447335 + 306 WP_021014717.1 type II toxin-antitoxin system toxin CcdB Toxin
CWC46_RS20305 4447804..4448529 + 726 WP_021014716.1 SDR family oxidoreductase -
CWC46_RS20310 4448625..4450231 - 1607 Protein_3919 hybrid sensor histidine kinase/response regulator -
CWC46_RS20315 4450228..4450731 - 504 Protein_3920 oxidoreductase -
CWC46_RS20320 4450724..4451710 - 987 WP_021014712.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4445315..4446334 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11833.77 Da        Isoelectric Point: 5.6202

>T89777 WP_021014717.1 NZ_CP025085:4447030-4447335 [Serratia sp. ATCC 39006]
MQFIVYQYKRTSHYKMFVDVQSDIVETPKRRMVIPLIESHHLSDKVNKTLFPLIRIDSEDYRLMTTELSNVPVEVIGEVI
ADLSKCSDEIKDAINLMFWGI

Download         Length: 306 bp

>T89777 NZ_CP025085:4447030-4447335 [Serratia sp. ATCC 39006]
ATGCAATTCATTGTTTATCAATACAAACGTACCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATATTGTCGAGAC
GCCAAAACGACGGATGGTCATCCCGCTTATCGAATCGCATCATCTGTCTGATAAAGTGAATAAAACGCTGTTTCCTCTGA
TCCGCATCGACAGCGAAGATTACCGGCTGATGACGACTGAACTATCGAACGTTCCTGTTGAGGTGATTGGTGAAGTGATT
GCAGATCTCAGCAAATGCTCAGATGAGATCAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8178.17 Da        Isoelectric Point: 8.6383

>AT89777 WP_021014718.1 NZ_CP025085:4446809-4447027 [Serratia sp. ATCC 39006]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDVIGKEARRIKAEAWKKENREGMEEVARFITQNGSFADENRNW

Download         Length: 219 bp

>AT89777 NZ_CP025085:4446809-4447027 [Serratia sp. ATCC 39006]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCTGGTCT
GGTGAATGATGTCATTGGCAAAGAAGCCCGCCGCATCAAAGCCGAAGCGTGGAAGAAAGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGGTTTATCACGCAGAATGGATCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5TNW0

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5TNW4

References