Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4391277..4391812 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name relE Uniprot ID A0A2I5TNR1
Locus tag CWC46_RS19970 Protein ID WP_021014780.1
Coordinates 4391525..4391812 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I5TBC6
Locus tag CWC46_RS19965 Protein ID WP_021014781.1
Coordinates 4391277..4391528 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS19940 4386280..4387809 - 1530 WP_021014786.1 conjugal transfer protein TraG N-terminal domain-containing protein -
CWC46_RS19945 4387821..4388174 - 354 WP_021014785.1 hypothetical protein -
CWC46_RS19950 4388171..4389589 - 1419 WP_021014784.1 integrating conjugative element protein -
CWC46_RS19955 4389600..4390574 - 975 WP_021014783.1 TIGR03756 family integrating conjugative element protein -
CWC46_RS19960 4390571..4390975 - 405 WP_021014782.1 TIGR03757 family integrating conjugative element protein -
CWC46_RS19965 4391277..4391528 + 252 WP_021014781.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CWC46_RS19970 4391525..4391812 + 288 WP_021014780.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWC46_RS19975 4391954..4392352 - 399 WP_021014779.1 hypothetical protein -
CWC46_RS19980 4392349..4395168 - 2820 WP_021014778.1 conjugative transfer ATPase -
CWC46_RS19985 4395168..4395575 - 408 WP_021014777.1 TIGR03751 family conjugal transfer lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4349590..4446334 96744


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11228.32 Da        Isoelectric Point: 10.4363

>T89776 WP_021014780.1 NZ_CP025085:4391525-4391812 [Serratia sp. ATCC 39006]
MSYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRMSGFRLVYQVIDDKLIIAVVAVGK
RERNDVYHLASERMR

Download         Length: 288 bp

>T89776 NZ_CP025085:4391525-4391812 [Serratia sp. ATCC 39006]
ATGAGCTACACGGTCAAATTCAGGGAAGATGCGCTGAAAGAATGGCAGAAACTGGATAAAGCCATTCAGCAACAGTTTGC
AAAAAAACTGAAAAAATGCTGTGAAAATCCACATATTCCTTCAGCTAAACTGCGTGGAATAAAAGACTGCTACAAAATAA
AACTTCGAATGTCTGGTTTTCGCCTGGTTTACCAAGTGATTGACGATAAATTAATTATCGCTGTTGTCGCTGTGGGTAAA
CGGGAACGAAACGATGTTTATCATCTGGCTAGCGAACGGATGAGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9188.55 Da        Isoelectric Point: 4.1789

>AT89776 WP_021014781.1 NZ_CP025085:4391277-4391528 [Serratia sp. ATCC 39006]
MPNIILSDMSASVSELKKNPMATVNAGEGFPVAILNRNQPAFYCVPAELYEKILNALDDQELVKLVAERSHQPLLDVDLD
SYL

Download         Length: 252 bp

>AT89776 NZ_CP025085:4391277-4391528 [Serratia sp. ATCC 39006]
ATGCCAAATATCATCCTAAGTGATATGAGTGCTAGTGTCAGCGAACTCAAGAAAAACCCTATGGCGACAGTCAACGCCGG
GGAGGGCTTTCCAGTTGCCATACTTAATCGCAACCAACCTGCTTTTTATTGCGTCCCTGCCGAACTGTACGAGAAGATAC
TTAATGCACTCGACGATCAGGAACTGGTGAAGCTGGTAGCCGAACGCAGCCACCAACCCCTGCTTGATGTGGATCTGGAT
AGCTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5TNR1

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5TBC6

References