Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3165184..3165816 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I5T8I6
Locus tag CWC46_RS14310 Protein ID WP_023220365.1
Coordinates 3165640..3165816 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2I5TKW7
Locus tag CWC46_RS14305 Protein ID WP_021015875.1
Coordinates 3165184..3165591 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS22890 3161051..3161212 + 162 WP_021015884.1 hypothetical protein -
CWC46_RS14260 3161205..3161528 + 324 WP_021015883.1 hypothetical protein -
CWC46_RS14265 3161636..3161878 - 243 WP_021015882.1 hypothetical protein -
CWC46_RS14270 3162006..3162449 + 444 WP_021015881.1 hypothetical protein -
CWC46_RS14275 3162657..3163205 - 549 WP_021015880.1 hypothetical protein -
CWC46_RS14280 3163358..3163564 - 207 WP_021015879.1 hypothetical protein -
CWC46_RS14290 3163729..3164262 - 534 WP_021015878.1 hypothetical protein -
CWC46_RS14295 3164235..3164765 - 531 WP_021015877.1 lysozyme -
CWC46_RS14300 3164768..3165007 - 240 WP_021015876.1 Lysis S family protein -
CWC46_RS14305 3165184..3165591 - 408 WP_021015875.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CWC46_RS14310 3165640..3165816 - 177 WP_023220365.1 type II toxin-antitoxin system HicA family toxin Toxin
CWC46_RS14315 3165986..3166561 - 576 WP_021015874.1 DUF1133 family protein -
CWC46_RS14320 3166558..3166917 - 360 WP_021015873.1 RusA family crossover junction endodeoxyribonuclease -
CWC46_RS14325 3166914..3167198 - 285 WP_021015872.1 DUF1364 family protein -
CWC46_RS14330 3167195..3167788 - 594 WP_021015871.1 DUF1367 family protein -
CWC46_RS14335 3167830..3168078 - 249 WP_021015870.1 hypothetical protein -
CWC46_RS14340 3168176..3169915 - 1740 WP_021015869.1 DNA cytosine methyltransferase -
CWC46_RS14345 3169912..3170670 - 759 WP_021015868.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3133282..3181506 48224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6695.76 Da        Isoelectric Point: 11.3427

>T89773 WP_023220365.1 NZ_CP025085:c3165816-3165640 [Serratia sp. ATCC 39006]
VKQSEFRRWLESQGVEVSNGTNHLKLRYNGNRSVMPRHPGAEIKEPLRKAILKQLGLK

Download         Length: 177 bp

>T89773 NZ_CP025085:c3165816-3165640 [Serratia sp. ATCC 39006]
GTGAAGCAAAGCGAGTTCAGGCGGTGGCTTGAATCTCAGGGAGTCGAAGTTTCAAACGGTACTAACCATTTGAAACTGAG
ATATAACGGAAATCGAAGCGTAATGCCAAGACATCCCGGCGCTGAGATAAAAGAACCGCTAAGAAAGGCCATACTCAAGC
AGTTAGGTCTTAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14728.87 Da        Isoelectric Point: 4.5822

>AT89773 WP_021015875.1 NZ_CP025085:c3165591-3165184 [Serratia sp. ATCC 39006]
MRYPVNLEPDTGGYVVSFPDVPEALTQGNTKEEALAMALGALVTSFEFYFEDNQRVPLPGEITGDYVEVPSSVAAKVIML
NAFVDSGLTQVELASRMGIKKQEVTRLFDLHHSTKIDTIQKAISALGKRLELVAA

Download         Length: 408 bp

>AT89773 NZ_CP025085:c3165591-3165184 [Serratia sp. ATCC 39006]
ATGCGATATCCTGTAAATTTAGAGCCAGACACTGGCGGATATGTGGTGAGCTTCCCTGACGTCCCCGAAGCATTAACTCA
GGGGAATACGAAAGAGGAAGCATTAGCGATGGCGCTTGGTGCATTGGTTACATCCTTTGAGTTTTACTTCGAGGACAATC
AGCGCGTGCCATTACCGGGAGAAATCACCGGTGATTATGTTGAGGTTCCGTCCAGCGTGGCCGCGAAAGTCATCATGCTA
AATGCTTTTGTAGATTCCGGCTTAACTCAGGTTGAGCTGGCGTCGCGTATGGGCATTAAAAAGCAGGAAGTAACACGGTT
GTTCGATCTGCATCACTCAACGAAAATAGACACCATTCAAAAGGCGATATCAGCACTAGGTAAACGCCTGGAGCTAGTCG
CCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5T8I6

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5TKW7

References