Detailed information of TA system TA089772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1414995..1415629
• Replicon: chromosome
• Accession: NZ_CP025085
• Organism: Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CWC46_RS06510
• Protein ID: WP_084297667.1
• Coordinates: 1415354..1415629 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A2I5TGY5
• Locus tag: CWC46_RS06505
• Protein ID: WP_021017063.1
• Coordinates: 1414995..1415357 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWC46_RS06475	1410414..1411100	-	687	WP_021017068.1	GntR family transcriptional regulator	-
CWC46_RS06480	1411393..1411524	+	132	WP_157831359.1	hypothetical protein	-
CWC46_RS06485	1411650..1412369	+	720	WP_021017067.1	molybdate ABC transporter substrate-binding protein	-
CWC46_RS06490	1412366..1413064	+	699	WP_021017066.1	ABC transporter permease subunit	-
CWC46_RS06495	1413064..1414167	+	1104	WP_021017065.1	molybdenum ABC transporter ATP-binding protein	-
CWC46_RS06500	1414191..1414580	+	390	Protein_1243	phage portal protein	-
CWC46_RS06505	1414995..1415357	-	363	WP_021017063.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CWC46_RS06510	1415354..1415629	-	276	WP_084297667.1	type II toxin-antitoxin system HicA family toxin	Toxin
CWC46_RS06515	1416035..1416979	+	945	WP_021017061.1	hypothetical protein	-
CWC46_RS06520	1417000..1417185	-	186	WP_037382366.1	hypothetical protein	-
CWC46_RS06530	1418156..1418710	-	555	WP_021017059.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1402026..1417541	15515

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10131.69 Da
• Isoelectric Point: 10.9754

>T89772 WP_084297667.1 NZ_CP025085:c1415629-1415354 [Serratia sp. ATCC 39006]
MQEKIAHLRKKQRETLNQIFKTPALSGVKWSNVESLITALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGAVVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T89772 NZ_CP025085:c1415629-1415354 [Serratia sp. ATCC 39006]
ATGCAGGAAAAAATAGCCCATCTTAGAAAGAAACAGCGGGAAACGCTGAACCAAATTTTCAAAACACCGGCACTCTCTGG
CGTTAAATGGTCGAATGTTGAGTCACTTATCACTGCGTTAGGCGGTGAGATTAAAGAAGGTAGTGGATCGAGGGTGCGAT
TTTTACTGAACGGGAGTATTGCCCGGTTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGCGCAGTGGTCAGCCTG
CGTGAATGGCTGGAAAGCATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13509.33 Da
• Isoelectric Point: 4.5189

>AT89772 WP_021017063.1 NZ_CP025085:c1415357-1414995 [Serratia sp. ATCC 39006]
MTKVLNTPNTMVVAGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSIDGLRSEGEISLREYLEDCQENSIEPYEREEKVK
TFTLRYPESFGERLTIAAAEHQVSVNAFIVEALNERMKHA

Nucleotide

• Length: 363 bp

>AT89772 NZ_CP025085:c1415357-1414995 [Serratia sp. ATCC 39006]
ATGACTAAAGTACTCAATACACCAAATACGATGGTTGTTGCCGGGCAACCGGCTATTATTAGTTACGTGCCTGAGATTGG
GATGTTTCGCGGTAAGTTTATTGGTCTATCAGGCTATTGTGATTTTGTTGCCGATAGCATTGATGGGCTGAGAAGTGAGG
GGGAAATCTCACTACGTGAATATCTGGAAGATTGTCAGGAAAACAGCATAGAGCCTTACGAGCGTGAGGAAAAAGTAAAA
ACCTTTACCCTCCGTTATCCTGAGTCATTCGGGGAACGGCTGACCATTGCTGCTGCTGAACACCAAGTTTCAGTGAATGC
GTTTATTGTCGAAGCGCTTAATGAACGGATGAAACACGCGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2I5TGY5