Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-sanaA/DUF6088(antitoxin)
Location 15422..16129 Replicon chromosome
Accession NZ_CP025085
Organism Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)


Gene name relE Uniprot ID A0A2I5T1A4
Locus tag CWC46_RS00090 Protein ID WP_021014233.1
Coordinates 15854..16129 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A2I5TDP0
Locus tag CWC46_RS00085 Protein ID WP_021014234.1
Coordinates 15422..15817 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC46_RS00055 10953..11129 - 177 WP_084297583.1 CopG family transcriptional regulator -
CWC46_RS23045 11518..11697 + 180 Protein_10 hypothetical protein -
CWC46_RS00060 11805..12125 + 321 WP_021014239.1 type II toxin-antitoxin system RelE/ParE family toxin -
CWC46_RS00065 12115..12399 + 285 WP_021014238.1 helix-turn-helix domain-containing protein -
CWC46_RS00075 12824..14079 - 1256 Protein_13 tyrosine-type recombinase/integrase -
CWC46_RS00080 14435..15241 - 807 WP_021014235.1 helix-turn-helix domain-containing protein -
CWC46_RS00085 15422..15817 - 396 WP_021014234.1 hypothetical protein Antitoxin
CWC46_RS00090 15854..16129 - 276 WP_021014233.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CWC46_RS00095 16133..16381 - 249 WP_021014232.1 ribbon-helix-helix domain-containing protein -
CWC46_RS00100 16491..17324 - 834 WP_021014231.1 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Protein of unknown function DUF6088

(8-111)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10904.11 Da        Isoelectric Point: 4.8732

>T89768 WP_021014233.1 NZ_CP025085:c16129-15854 [Serratia sp. ATCC 39006]
MEILWTQKAQDDLERIYGFASQYSRQHADDVLDRLIIGTTGLADHPRVGVSQTRYEPREVRKILFDDYEVHYEIQHDAVY
IVDLWHTREDR

Download         Length: 276 bp

>T89768 NZ_CP025085:c16129-15854 [Serratia sp. ATCC 39006]
ATGGAAATACTTTGGACGCAAAAGGCACAGGATGACCTGGAACGTATCTATGGGTTTGCCAGTCAGTACAGTCGGCAACA
TGCTGACGATGTGTTAGATCGCTTGATCATTGGAACAACAGGGCTTGCCGACCATCCACGAGTCGGCGTATCTCAGACAA
GGTATGAACCACGCGAGGTGAGAAAAATTCTGTTTGATGATTATGAAGTTCACTATGAAATTCAGCATGATGCTGTTTAT
ATTGTCGATCTTTGGCATACGAGGGAAGATCGCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14319.57 Da        Isoelectric Point: 10.7741

>AT89768 WP_021014234.1 NZ_CP025085:c15817-15422 [Serratia sp. ATCC 39006]
MTTKDCIQSRLKRSKRYVFTRDDFKDIGSYGQVGKVLRSLVKDGLLLKVGYGIYTKARRNSITGNIMPAAPGGSSAVIIE
VLDRLNVPYRFVGATAAYNSGKSTQIPVSLEIETSSRFKRVLIVGSSNLNG

Download         Length: 396 bp

>AT89768 NZ_CP025085:c15817-15422 [Serratia sp. ATCC 39006]
ATGACGACGAAAGATTGTATTCAGTCCAGACTGAAGCGTTCAAAGCGTTATGTTTTTACTCGTGATGACTTCAAAGATAT
TGGGAGCTATGGCCAAGTTGGCAAAGTGTTACGTAGCCTGGTTAAGGATGGGTTGTTGCTGAAGGTAGGCTATGGGATAT
ATACCAAAGCTCGTCGAAACAGCATTACCGGCAACATTATGCCTGCTGCGCCAGGGGGGTCTTCTGCCGTGATTATTGAA
GTTCTGGATCGCTTAAATGTACCTTATCGTTTCGTTGGCGCAACAGCAGCATATAACAGCGGCAAGTCCACGCAGATCCC
AGTCTCTCTGGAAATAGAAACCTCATCGCGTTTTAAAAGGGTGCTTATCGTAGGGAGCAGCAACCTCAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5T1A4

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5TDP0

References