Detailed information of TA system TA089767

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 9002..10646
• Replicon: chromosome
• Accession: NZ_CP025085
• Organism: Serratia sp. ATCC 39006 strain LacA

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2I5TDL9
• Locus tag: CWC46_RS00045
• Protein ID: WP_021014243.1
• Coordinates: 9002..10336 (-)
• Length: 445 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: CWC46_RS00050
• Protein ID: WP_021014242.1
• Coordinates: 10341..10646 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CWC46_RS00020	4137..5372	+	1236	WP_021014248.1	glucuronoarabinoxylan endo-1,4-beta-xylanase	-
CWC46_RS00025	5532..6881	-	1350	WP_021014247.1	MFS transporter	-
CWC46_RS00030	7555..7884	+	330	WP_021014246.1	hypothetical protein	-
CWC46_RS00035	7925..8479	+	555	WP_021014245.1	glycine zipper family protein	-
CWC46_RS00040	8491..8897	+	407	Protein_6	DNA primase	-
CWC46_RS00045	9002..10336	-	1335	WP_021014243.1	type II toxin-antitoxin system HipA family toxin	Toxin
CWC46_RS00050	10341..10646	-	306	WP_021014242.1	helix-turn-helix domain-containing protein	Antitoxin
CWC46_RS00055	10953..11129	-	177	WP_084297583.1	CopG family transcriptional regulator	-
CWC46_RS23045	11518..11697	+	180	Protein_10	hypothetical protein	-
CWC46_RS00060	11805..12125	+	321	WP_021014239.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CWC46_RS00065	12115..12399	+	285	WP_021014238.1	helix-turn-helix domain-containing protein	-
CWC46_RS00075	12824..14079	-	1256	Protein_13	tyrosine-type recombinase/integrase	-
CWC46_RS00080	14435..15241	-	807	WP_021014235.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	8488..14079	5591

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 445 a.a.
• Molecular weight: 50584.86 Da
• Isoelectric Point: 6.2391

>T89767 WP_021014243.1 NZ_CP025085:c10336-9002 [Serratia sp. ATCC 39006]
MRRTQQRLAIWMNGIQVGFWGKARGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
AMRYQAASLEPFDLLAELGKDCVGAIQLLNVDEEPTDLFSINHRPLSEAEIAARLRNITAALLPGRQGDTDDLRLSIAGA
QEKTALLWHEEQWCLPEGSTPTTHIFKLPLGLVGNMQANMSTSVENEWLCSLILEAYGVPVAKTRIAQFEEQKALVVERF
DRRWSGDRQWIVRLPQEDMCQALGVSPLRKYQSDGGPSISDIMAILSHSDQAERDKALFFMAQIIFWLIAATDGHAKNFS
IAIEPQGHYHLTPLYDVLSVWPVIGPDNNHISWQKCKLAMAVRGSSNYYHLHRIQRRHWIKQGELTGLGRVQVESMMDEI
ISRTPEVIERVSALLPESFPPELAECVFDGMRQQCGRLQELHRK

Nucleotide

• Length: 1335 bp

>T89767 NZ_CP025085:c10336-9002 [Serratia sp. ATCC 39006]
ATGCGTCGTACACAACAGCGTTTAGCGATATGGATGAACGGGATCCAGGTTGGATTCTGGGGAAAGGCCAGAGGTGAAGA
TAGGTTGCAATATCTTCCGGAATGGATTGCTGATGAACAGGGAAGACCTTTATCGCTCTCTTTGCTTTTCACCCCCGGTA
ATCAGCTTTGGCGCGGCAACGTAGTACGTGACTATTTTGATAATTTATTGCCTGACAGCGAAGGCATTCGCAGGCGTTTG
GCAATGCGTTACCAAGCAGCAAGTCTTGAGCCTTTTGATCTGCTGGCTGAGTTGGGAAAAGACTGTGTTGGCGCAATACA
GTTACTGAATGTTGATGAAGAGCCCACGGATTTATTCTCCATAAACCATCGCCCGCTTTCTGAAGCAGAGATAGCCGCAA
GATTGCGTAATATCACGGCAGCTTTATTGCCTGGTCGGCAGGGCGATACTGATGATTTGCGCTTATCAATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTGTGGCATGAAGAACAATGGTGTTTGCCAGAAGGCAGTACCCCAACGACGCATATTTTCAA
GTTACCACTCGGGCTGGTTGGTAATATGCAAGCGAATATGAGCACGTCGGTTGAAAATGAATGGCTATGTTCTTTGATTC
TTGAGGCGTATGGGGTCCCGGTTGCAAAAACGCGGATTGCGCAGTTTGAAGAGCAGAAGGCACTGGTTGTTGAGCGTTTT
GACAGGAGATGGTCGGGCGATCGGCAATGGATCGTTCGCTTGCCACAAGAGGATATGTGTCAAGCTCTGGGTGTTTCTCC
ACTACGAAAATACCAGTCTGATGGTGGGCCGAGTATTTCCGATATTATGGCCATACTGAGTCATTCAGACCAGGCTGAAC
GGGACAAAGCGTTGTTCTTCATGGCGCAAATTATTTTCTGGCTGATAGCGGCCACTGATGGACATGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCATTATCACCTTACGCCTCTTTATGATGTTTTATCGGTATGGCCAGTCATTGGTCCTGA
TAATAACCATATTTCCTGGCAGAAGTGCAAACTGGCAATGGCAGTTCGCGGTAGCAGTAATTATTACCACCTGCACAGAA
TTCAACGGCGGCATTGGATCAAGCAGGGTGAATTAACCGGTCTGGGCAGAGTACAGGTTGAATCCATGATGGATGAAATT
ATATCCAGAACACCTGAGGTTATTGAACGTGTATCTGCGTTGTTGCCGGAGTCGTTTCCACCAGAGCTTGCGGAATGTGT
GTTTGATGGTATGCGGCAGCAGTGTGGTCGGTTACAAGAACTGCATCGTAAATAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11268.90 Da
• Isoelectric Point: 10.0912

>AT89767 WP_021014242.1 NZ_CP025085:c10646-10341 [Serratia sp. ATCC 39006]
MNTVYPLKTLNQLRPLLIGFRKANGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVFTVLGVEVVLSSEPRELFSA
SSSTMEGGEKPIDSPTRREKW

Nucleotide

• Length: 306 bp

>AT89767 NZ_CP025085:c10646-10341 [Serratia sp. ATCC 39006]
ATGAATACTGTTTATCCATTGAAAACCTTGAATCAGCTGCGTCCATTGCTGATTGGCTTTCGCAAAGCTAATGGACTGAC
GCAAAAAGACGTGTCTGAAAGGCTAGGTGTAACACAGCAAACCTATGCCCGTCTGGAAGCAAACCCTGGAAGTGCCAGCA
TTGAGCGCTTGTTTAAGGTGTTTACTGTACTGGGGGTTGAAGTGGTGCTCTCTTCTGAACCAAGGGAGCTCTTCTCTGCG
TCATCTTCAACCATGGAAGGGGGAGAAAAGCCAATAGATTCCCCTACCCGACGGGAAAAATGGTGA

Structures

Toxin

• AlphaFold DB: A0A2I5TDL9