Detailed information of TA system TA089766

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4772099..4772777
• Replicon: chromosome
• Accession: NZ_CP025084
• Organism: Serratia sp. ATCC 39006

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: G4V4G3
• Locus tag: SER39006_RS21755
• Protein ID: WP_037380577.1
• Coordinates: 4772099..4772530 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G4V4G2
• Locus tag: SER39006_RS21760
• Protein ID: WP_021014431.1
• Coordinates: 4772511..4772777 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SER39006_RS21735	4767422..4768258	+	837	WP_021014436.1	2-keto-3-deoxy-L-rhamnonate aldolase	-
SER39006_RS21740	4768600..4769925	+	1326	WP_021014435.1	MHS family MFS transporter	-
SER39006_RS21745	4770276..4770794	+	519	WP_021014434.1	flavodoxin FldB	-
SER39006_RS21750	4770966..4771898	-	933	WP_021014433.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
SER39006_RS21755	4772099..4772530	-	432	WP_037380577.1	protein YgfX	Toxin
SER39006_RS21760	4772511..4772777	-	267	WP_021014431.1	FAD assembly factor SdhE	Antitoxin
SER39006_RS21765	4773049..4774035	+	987	WP_021014430.1	tRNA-modifying protein YgfZ	-
SER39006_RS21770	4774103..4774750	-	648	WP_021014429.1	hemolysin III family protein	-
SER39006_RS21775	4774977..4775585	+	609	WP_021014428.1	HD domain-containing protein	-
SER39006_RS21780	4775954..4776886	+	933	WP_021014427.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-134)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 17244.29 Da
• Isoelectric Point: 11.6141

>T89766 WP_037380577.1 NZ_CP025084:c4772530-4772099 [Serratia sp. ATCC 39006]
VVQWQCNLRVSWRMQLFSLLAHGLLVLLILLAPWPDGYMSVWLGLVTLVMFGFIRSQRNIKSRHGEIVLYNENHLRWQHR
EWQITKRPWVLKNGILLSLRTTEGKGPRRRSLWLASDSMRNEEWRHLCHLLLQHKNWQSDRLM

Nucleotide

• Length: 432 bp

>T89766 NZ_CP025084:c4772530-4772099 [Serratia sp. ATCC 39006]
GTGGTCCAGTGGCAATGTAATTTGCGGGTTTCCTGGCGTATGCAGCTTTTCTCGTTGCTGGCGCACGGATTATTGGTGTT
GCTGATTTTGCTGGCTCCTTGGCCAGATGGTTATATGTCTGTCTGGCTGGGGCTGGTGACATTGGTGATGTTTGGTTTTA
TTCGCAGTCAACGGAATATTAAATCCCGGCATGGGGAGATTGTGCTATATAACGAAAACCATCTGCGTTGGCAGCACCGG
GAATGGCAAATAACAAAACGTCCGTGGGTATTGAAAAACGGTATCCTGTTATCGTTGCGCACGACAGAGGGTAAAGGCCC
GCGTCGCCGCAGTTTATGGCTGGCGTCGGACAGTATGAGGAACGAGGAGTGGCGTCATTTGTGTCATTTGCTGTTGCAGC
ATAAGAACTGGCAGAGTGATCGCCTGATGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10486.94 Da
• Isoelectric Point: 6.0648

>AT89766 WP_021014431.1 NZ_CP025084:c4772777-4772511 [Serratia sp. ATCC 39006]
MDIDNKPRIHWACRRGMRELDISIMPFFEHDYDTLSDDDKRNFIRLLQCDDPDLFNWLMNHGEPTDQGLKHMVSLIQTRN
KNRGPVAM

Nucleotide

• Length: 267 bp

>AT89766 NZ_CP025084:c4772777-4772511 [Serratia sp. ATCC 39006]
ATGGATATCGATAATAAACCACGTATTCACTGGGCGTGTCGACGCGGAATGCGTGAGCTGGATATTTCAATCATGCCGTT
TTTTGAGCATGACTATGACACACTGAGTGACGACGATAAGCGTAATTTTATCCGTCTATTGCAGTGCGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGCGAGCCAACGGATCAGGGCTTGAAGCATATGGTTTCCCTTATTCAAACGCGAAAT
AAAAACCGTGGTCCAGTGGCAATGTAA

Structures

Toxin

• AlphaFold DB: G4V4G3

Antitoxin

• AlphaFold DB: G4V4G2