Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2594..3202 Replicon plasmid unnamed3
Accession NZ_CP025064
Organism Roseomonas mucosa strain PG

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HVPorG_RS22245 Protein ID WP_265548292.1
Coordinates 2918..3202 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HVPorG_RS22240 Protein ID WP_265548291.1
Coordinates 2594..2905 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HVPorG_RS22230 (HVPorG_04178) 1..824 - 824 WP_265548290.1 transposase -
HVPorG_RS22235 (HVPorG_04559a) 1028..2054 - 1027 Protein_1 IS3 family transposase -
HVPorG_RS22240 (HVPorG_04703) 2594..2905 - 312 WP_265548291.1 HigA family addiction module antitoxin Antitoxin
HVPorG_RS22245 2918..3202 - 285 WP_265548292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HVPorG_RS22250 3359..3508 - 150 WP_265548293.1 hypothetical protein -
HVPorG_RS22255 (HVPorG_02113) 3640..4290 - 651 WP_265548294.1 ParA family protein -
HVPorG_RS22260 (HVPorG_04704) 4731..5204 + 474 WP_265548295.1 hypothetical protein -
HVPorG_RS22265 (HVPorG_04559b) 5263..6174 + 912 Protein_7 IS3 family transposase -
HVPorG_RS22270 (HVPorG_04178a) 6378..7445 + 1068 WP_265548296.1 IS110 family transposase -
HVPorG_RS22275 (HVPorG_04179a) 7462..7677 + 216 Protein_9 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..111031 111031
- inside IScluster/Tn - - 959..7677 6718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10895.51 Da        Isoelectric Point: 9.2045

>T89691 WP_265548292.1 NZ_CP025064:c3202-2918 [Roseomonas mucosa]
MIQSFKDDATRRLFEGSRVFGVGWEQVQKIARRKLLMLHAAVILDDLRSPPGNMLESLQGNRVGQHSIRVNGQWRVCFVW
RPDGPHEVEVIDYH

Download         Length: 285 bp

>T89691 NZ_CP025064:c3202-2918 [Roseomonas mucosa]
TTGATTCAGTCGTTCAAGGATGATGCCACCCGGCGTCTCTTCGAGGGCAGCCGTGTCTTCGGGGTCGGCTGGGAGCAAGT
TCAGAAGATCGCAAGGCGGAAGCTGCTCATGCTGCACGCCGCAGTGATCCTAGATGATTTACGCAGCCCGCCGGGGAACA
TGTTGGAGTCGTTACAGGGCAACAGAGTTGGCCAGCACTCGATTCGAGTGAATGGCCAATGGCGGGTGTGCTTCGTGTGG
CGCCCGGACGGCCCCCATGAGGTCGAAGTGATAGACTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11455.93 Da        Isoelectric Point: 4.6830

>AT89691 WP_265548291.1 NZ_CP025064:c2905-2594 [Roseomonas mucosa]
MVDRDLVIHPGEILMEEFLRPHGLTPSGFASRLDLPANRITAIVNGERGISSETAVLLAAAFGTTEAFWLNLQSQYDLEQ
AHASVSPERIRKARELHDEFEAI

Download         Length: 312 bp

>AT89691 NZ_CP025064:c2905-2594 [Roseomonas mucosa]
ATGGTTGATCGTGACTTGGTGATCCATCCAGGCGAGATCCTGATGGAGGAGTTCCTACGTCCGCACGGGCTGACGCCCAG
TGGCTTCGCATCGCGCCTAGACCTACCGGCGAACCGTATTACCGCGATCGTCAATGGCGAGCGGGGCATCTCTTCGGAAA
CGGCCGTGCTGCTGGCGGCGGCCTTTGGCACCACGGAGGCATTCTGGTTGAACCTTCAGAGCCAGTACGACCTGGAGCAA
GCCCATGCTTCCGTATCACCGGAGCGGATCCGGAAGGCGCGCGAGCTGCATGACGAATTCGAGGCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References