Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1844713..1845548 Replicon chromosome
Accession NZ_CP025048
Organism Escherichia coli strain SC516

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7W4PV54
Locus tag CWI33_RS09290 Protein ID WP_000854821.1
Coordinates 1845171..1845548 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CWI33_RS09285 Protein ID WP_032216526.1
Coordinates 1844713..1845081 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWI33_RS09245 1839845..1840729 + 885 WP_000010399.1 50S ribosome-binding GTPase -
CWI33_RS09250 1840848..1841525 + 678 WP_001097362.1 hypothetical protein -
CWI33_RS09255 1841531..1841764 + 234 WP_001278288.1 DUF905 family protein -
CWI33_RS09260 1841854..1842672 + 819 WP_100881928.1 DUF945 domain-containing protein -
CWI33_RS09265 1842764..1843249 + 486 WP_032216512.1 antirestriction protein -
CWI33_RS09270 1843265..1843741 + 477 WP_001186724.1 RadC family protein -
CWI33_RS09275 1843810..1844031 + 222 WP_001601167.1 DUF987 domain-containing protein -
CWI33_RS09280 1844050..1844694 + 645 Protein_1713 antitoxin of toxin-antitoxin stability system -
CWI33_RS09285 1844713..1845081 + 369 WP_032216526.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CWI33_RS09290 1845171..1845548 + 378 WP_000854821.1 type IV toxin-antitoxin system toxin CbtA Toxin
CWI33_RS09295 1845545..1845694 + 150 Protein_1716 hypothetical protein -
CWI33_RS09300 1845770..1845967 + 198 WP_023563519.1 DUF957 domain-containing protein -
CWI33_RS09305 1846052..1846894 + 843 WP_001280501.1 DUF4942 domain-containing protein -
CWI33_RS09310 1847176..1847712 - 537 WP_063091691.1 GspM family type II secretion system protein YghD -
CWI33_RS09315 1847714..1848892 - 1179 WP_000094962.1 type II secretion system protein GspL -
CWI33_RS09320 1848889..1849866 - 978 WP_072643195.1 type II secretion system minor pseudopilin GspK -
CWI33_RS09325 1849869..1850468 - 600 WP_072643194.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - papC / papD / gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC 1783285..1907772 124487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13930.95 Da        Isoelectric Point: 8.5163

>T89637 WP_000854821.1 NZ_CP025048:1845171-1845548 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T89637 NZ_CP025048:1845171-1845548 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13810.69 Da        Isoelectric Point: 6.2066

>AT89637 WP_032216526.1 NZ_CP025048:1844713-1845081 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT89637 NZ_CP025048:1844713-1845081 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCTCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGTCGACCGCGCCGGCATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7W4PV54


Antitoxin

Source ID Structure

References