Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 5212330..5212862 Replicon chromosome
Accession NZ_CP024985
Organism Streptomyces lavendulae subsp. lavendulae strain CCM 3239

Toxin (Protein)


Gene name relE Uniprot ID A0A2K8PI76
Locus tag SLAV_RS23070 Protein ID WP_030240465.1
Coordinates 5212330..5212593 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2K8PI77
Locus tag SLAV_RS23075 Protein ID WP_030240463.1
Coordinates 5212590..5212862 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLAV_RS23045 5207747..5208709 + 963 WP_030240471.1 permease-like cell division protein FtsX -
SLAV_RS23050 5208790..5209947 - 1158 Protein_4478 transposase -
SLAV_RS23055 5210081..5211265 + 1185 WP_030240468.1 PDZ domain-containing protein -
SLAV_RS23060 5211284..5211769 + 486 WP_030240466.1 SsrA-binding protein SmpB -
SLAV_RS23070 5212330..5212593 - 264 WP_030240465.1 Txe/YoeB family addiction module toxin Toxin
SLAV_RS23075 5212590..5212862 - 273 WP_030240463.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SLAV_RS41830 5213005..5214228 - 1224 WP_051841488.1 SH3 domain-containing protein -
SLAV_RS23095 5214274..5215557 - 1284 WP_208754752.1 MFS transporter -
SLAV_RS23100 5215676..5216644 + 969 WP_030239199.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-71)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10278.65 Da        Isoelectric Point: 8.4857

>T89419 WP_030240465.1 NZ_CP024985:c5212593-5212330 [Streptomyces lavendulae subsp. lavendulae]
VRSVHFDPDAWEDFLFWLGADRKMARRITRLIGEIQSSPFAGIGKPEPLKGDLTGYWSRRIDDEHRLVYRADDKEVKILK
ARYHYSD

Download         Length: 264 bp

>T89419 NZ_CP024985:c5212593-5212330 [Streptomyces lavendulae subsp. lavendulae]
GTGAGGAGCGTCCACTTCGACCCGGACGCCTGGGAGGACTTCCTGTTCTGGCTCGGGGCGGACCGCAAGATGGCCAGGCG
GATCACCCGCCTGATCGGCGAGATCCAGAGCTCTCCGTTCGCGGGCATCGGAAAGCCCGAACCCCTCAAGGGTGACCTGA
CGGGCTACTGGTCCCGCCGGATCGACGACGAGCACCGTCTCGTCTACCGGGCCGACGACAAGGAAGTGAAGATCCTCAAA
GCCCGGTACCACTACTCGGACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9962.24 Da        Isoelectric Point: 4.6286

>AT89419 WP_030240463.1 NZ_CP024985:c5212862-5212590 [Streptomyces lavendulae subsp. lavendulae]
MPISASEARKTLFPLIERVNDDHVPVRISSKNGDAVLMSAADYDSWQETVYLLRSPANARRLMEAVARDREGIASVTKSM
EELQALAGDE

Download         Length: 273 bp

>AT89419 NZ_CP024985:c5212862-5212590 [Streptomyces lavendulae subsp. lavendulae]
ATGCCCATAAGCGCCAGCGAGGCACGCAAGACCCTGTTCCCCCTCATCGAGCGCGTCAACGACGACCACGTACCCGTGCG
CATCAGCTCCAAGAACGGGGACGCGGTCCTCATGTCGGCCGCCGACTACGACTCCTGGCAGGAGACGGTCTACCTGCTGC
GCTCTCCCGCGAACGCCCGCCGGCTGATGGAAGCCGTCGCCCGCGACAGGGAAGGGATCGCGAGCGTTACGAAGAGCATG
GAGGAACTCCAGGCCCTGGCCGGTGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PI76

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8PI77

References