Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 4447561..4448405 | Replicon | chromosome |
| Accession | NZ_CP024900 | ||
| Organism | Photorhabdus laumondii subsp. laumondii strain DJC | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | Q7N0E6 |
| Locus tag | PluDJC_RS19610 | Protein ID | WP_011148078.1 |
| Coordinates | 4447917..4448405 (+) | Length | 163 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | Q7N0E7 |
| Locus tag | PluDJC_RS19605 | Protein ID | WP_011148077.1 |
| Coordinates | 4447561..4447911 (+) | Length | 117 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PluDJC_RS19580 | 4442603..4443202 | + | 600 | WP_109791819.1 | hypothetical protein | - |
| PluDJC_RS19585 | 4443213..4444328 | + | 1116 | WP_011148073.1 | XRE family transcriptional regulator | - |
| PluDJC_RS19590 | 4444475..4444900 | - | 426 | WP_011148074.1 | TonB system transport protein ExbD | - |
| PluDJC_RS19595 | 4444904..4445875 | - | 972 | WP_041381122.1 | tonB-system energizer ExbB | - |
| PluDJC_RS19600 | 4446222..4447412 | + | 1191 | WP_011148076.1 | cystathionine beta-lyase | - |
| PluDJC_RS19605 | 4447561..4447911 | + | 351 | WP_011148077.1 | type II toxin-antitoxin system PrlF family antitoxin | Antitoxin |
| PluDJC_RS19610 | 4447917..4448405 | + | 489 | WP_011148078.1 | type II toxin-antitoxin system YhaV family toxin | Toxin |
| PluDJC_RS19615 | 4448550..4449221 | + | 672 | WP_011148079.1 | DedA family protein | - |
| PluDJC_RS19620 | 4449621..4450499 | + | 879 | WP_011148080.1 | 2,5-didehydrogluconate reductase DkgA | - |
| PluDJC_RS19625 | 4450634..4452055 | - | 1422 | WP_011148081.1 | cell division protein FtsP | - |
| PluDJC_RS19630 | 4452460..4453188 | - | 729 | WP_011148082.1 | 1-acylglycerol-3-phosphate O-acyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 163 a.a. Molecular weight: 19108.94 Da Isoelectric Point: 9.5494
>T89184 WP_011148078.1 NZ_CP024900:4447917-4448405 [Photorhabdus laumondii subsp. laumondii]
MYDRVCVINGWALFAHPCFVEQLKQSIDKVEQLQQKYPNDYLKKNDTKRLAAIIKLVTEIIPNDPTNIAFRLGDTLGGKR
KHWFRAKFFQQYRLFFRFHAESKIIIFGWVNDERTKRAYGDKHDAYKVFGEMLNAGHPPDDWNSLLKESIDSPHLTKLIN
EH
MYDRVCVINGWALFAHPCFVEQLKQSIDKVEQLQQKYPNDYLKKNDTKRLAAIIKLVTEIIPNDPTNIAFRLGDTLGGKR
KHWFRAKFFQQYRLFFRFHAESKIIIFGWVNDERTKRAYGDKHDAYKVFGEMLNAGHPPDDWNSLLKESIDSPHLTKLIN
EH
Download Length: 489 bp
>T89184 NZ_CP024900:4447917-4448405 [Photorhabdus laumondii subsp. laumondii]
ATGTATGATCGAGTATGTGTAATAAACGGATGGGCTCTTTTTGCTCATCCGTGCTTTGTAGAACAATTAAAACAATCAAT
AGATAAGGTAGAACAACTTCAACAAAAATATCCAAATGACTACTTGAAAAAAAATGATACAAAACGCTTGGCTGCAATCA
TAAAACTCGTTACTGAAATTATTCCCAATGACCCAACTAATATAGCCTTTCGTTTAGGTGACACATTAGGTGGCAAAAGA
AAACACTGGTTCAGAGCAAAATTTTTCCAACAATATCGCCTTTTTTTCCGTTTTCACGCTGAAAGTAAAATTATTATCTT
TGGCTGGGTAAATGATGAGAGAACAAAAAGGGCATATGGTGATAAGCACGATGCTTACAAAGTATTTGGTGAAATGCTTA
ATGCAGGACACCCACCAGACGACTGGAACTCTCTTTTAAAAGAATCCATTGATTCACCACACTTAACTAAACTTATTAAT
GAACATTAG
ATGTATGATCGAGTATGTGTAATAAACGGATGGGCTCTTTTTGCTCATCCGTGCTTTGTAGAACAATTAAAACAATCAAT
AGATAAGGTAGAACAACTTCAACAAAAATATCCAAATGACTACTTGAAAAAAAATGATACAAAACGCTTGGCTGCAATCA
TAAAACTCGTTACTGAAATTATTCCCAATGACCCAACTAATATAGCCTTTCGTTTAGGTGACACATTAGGTGGCAAAAGA
AAACACTGGTTCAGAGCAAAATTTTTCCAACAATATCGCCTTTTTTTCCGTTTTCACGCTGAAAGTAAAATTATTATCTT
TGGCTGGGTAAATGATGAGAGAACAAAAAGGGCATATGGTGATAAGCACGATGCTTACAAAGTATTTGGTGAAATGCTTA
ATGCAGGACACCCACCAGACGACTGGAACTCTCTTTTAAAAGAATCCATTGATTCACCACACTTAACTAAACTTATTAAT
GAACATTAG
Antitoxin
Download Length: 117 a.a. Molecular weight: 12842.53 Da Isoelectric Point: 4.9246
>AT89184 WP_011148077.1 NZ_CP024900:4447561-4447911 [Photorhabdus laumondii subsp. laumondii]
MHALPNVEFEVGAESKLTSRSQTTIPTSVRKALKLKPGHDSIAYKILSSGDVLISRKNSEEEKDLVMESFLDFLAKDIRR
HPGQVQQLDEQLINQAKSLIAGIDIDLSNPLSADDE
MHALPNVEFEVGAESKLTSRSQTTIPTSVRKALKLKPGHDSIAYKILSSGDVLISRKNSEEEKDLVMESFLDFLAKDIRR
HPGQVQQLDEQLINQAKSLIAGIDIDLSNPLSADDE
Download Length: 351 bp
>AT89184 NZ_CP024900:4447561-4447911 [Photorhabdus laumondii subsp. laumondii]
ATGCACGCATTACCAAATGTTGAGTTCGAGGTTGGTGCAGAATCCAAGCTTACCAGTCGCAGCCAGACAACCATCCCAAC
ATCTGTCCGTAAAGCGCTTAAGTTAAAACCAGGTCATGACAGTATCGCATATAAGATTTTATCTTCTGGTGATGTACTTA
TCAGCCGTAAAAATAGTGAAGAAGAAAAAGATCTTGTCATGGAATCATTTCTGGACTTTCTGGCAAAAGACATTCGGAGA
CATCCGGGACAAGTACAACAATTAGATGAACAACTCATTAACCAGGCGAAGTCACTTATCGCTGGAATAGACATAGATCT
GAGCAACCCATTATCTGCTGACGATGAGTAA
ATGCACGCATTACCAAATGTTGAGTTCGAGGTTGGTGCAGAATCCAAGCTTACCAGTCGCAGCCAGACAACCATCCCAAC
ATCTGTCCGTAAAGCGCTTAAGTTAAAACCAGGTCATGACAGTATCGCATATAAGATTTTATCTTCTGGTGATGTACTTA
TCAGCCGTAAAAATAGTGAAGAAGAAAAAGATCTTGTCATGGAATCATTTCTGGACTTTCTGGCAAAAGACATTCGGAGA
CATCCGGGACAAGTACAACAATTAGATGAACAACTCATTAACCAGGCGAAGTCACTTATCGCTGGAATAGACATAGATCT
GAGCAACCCATTATCTGCTGACGATGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JMX9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6L9JML2 |