Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4016074..4016908 Replicon chromosome
Accession NZ_CP024886
Organism Escherichia coli strain AR_0017

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag AM344_RS20910 Protein ID WP_000854689.1
Coordinates 4016074..4016451 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag AM344_RS20915 Protein ID WP_001285599.1
Coordinates 4016528..4016908 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM344_RS20870 4011320..4012717 + 1398 WP_000404886.1 PTS ascorbate transporter subunit IIC -
AM344_RS20875 4012733..4013038 + 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
AM344_RS20880 4013048..4013512 + 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
AM344_RS20885 4013526..4014176 + 651 WP_000056749.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
AM344_RS20895 4014448..4015266 - 819 WP_001545729.1 DUF4942 domain-containing protein -
AM344_RS20900 4015380..4015577 - 198 WP_000839236.1 DUF957 domain-containing protein -
AM344_RS20905 4015589..4016077 - 489 WP_001530850.1 hypothetical protein -
AM344_RS20910 4016074..4016451 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
AM344_RS20915 4016528..4016908 - 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM344_RS20920 4016958..4017602 - 645 WP_000086755.1 hypothetical protein -
AM344_RS20925 4017621..4017842 - 222 WP_000692345.1 DUF987 domain-containing protein -
AM344_RS20930 4017911..4018387 - 477 WP_001424026.1 RadC family protein -
AM344_RS20935 4018403..4018876 - 474 WP_000855059.1 antirestriction protein -
AM344_RS20945 4019217..4020038 - 822 WP_016244184.1 DUF945 domain-containing protein -
AM344_RS27230 4020139..4020347 - 209 Protein_3852 DUF905 domain-containing protein -
AM344_RS20955 4020448..4020903 - 456 WP_000581493.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T89116 WP_000854689.1 NZ_CP024886:c4016451-4016074 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T89116 NZ_CP024886:c4016451-4016074 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT89116 WP_001285599.1 NZ_CP024886:c4016908-4016528 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT89116 NZ_CP024886:c4016908-4016528 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References