Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1571077..1571908 Replicon chromosome
Accession NZ_CP024855
Organism Escherichia coli strain AR_0011

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag AM338_RS08205 Protein ID WP_000854818.1
Coordinates 1571534..1571908 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag AM338_RS08200 Protein ID WP_001313071.1
Coordinates 1571077..1571445 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM338_RS08150 1566403..1566948 - 546 WP_000973176.1 bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase -
AM338_RS08165 1567573..1568270 + 698 Protein_1485 IS1-like element IS1A family transposase -
AM338_RS08170 1568349..1568618 + 270 WP_000995808.1 hypothetical protein -
AM338_RS08180 1568839..1569660 + 822 WP_001234530.1 DUF945 domain-containing protein -
AM338_RS08185 1569742..1570221 + 480 WP_000860076.1 antirestriction protein -
AM338_RS08190 1570237..1570713 + 477 WP_001186726.1 RadC family protein -
AM338_RS08195 1570776..1570997 + 222 WP_000692301.1 DUF987 domain-containing protein -
AM338_RS08200 1571077..1571445 + 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM338_RS08205 1571534..1571908 + 375 WP_000854818.1 type IV toxin-antitoxin system toxin CbtA Toxin
AM338_RS08210 1571905..1572099 + 195 WP_000988600.1 hypothetical protein -
AM338_RS26985 1572112..1572225 + 114 WP_001161660.1 DUF957 domain-containing protein -
AM338_RS08215 1572514..1572660 - 147 Protein_1495 transposase domain-containing protein -
AM338_RS08220 1572714..1572896 + 183 WP_001016348.1 hypothetical protein -
AM338_RS08225 1572997..1573326 - 330 WP_000450409.1 DUF496 family protein -
AM338_RS08230 1573498..1574556 - 1059 WP_001200905.1 FUSC family protein -
AM338_RS08235 1574754..1575227 - 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
AM338_RS08240 1575284..1576504 - 1221 WP_000343760.1 ISL3-like element ISKox3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1575284..1576504 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T88875 WP_000854818.1 NZ_CP024855:1571534-1571908 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T88875 NZ_CP024855:1571534-1571908 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT88875 WP_001313071.1 NZ_CP024855:1571077-1571445 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT88875 NZ_CP024855:1571077-1571445 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References