Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1601122..1601638 Replicon chromosome
Accession NZ_CP024838
Organism Klebsiella pneumoniae strain CRKP-1215

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag CU074_RS07880 Protein ID WP_009486548.1
Coordinates 1601122..1601406 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CU074_RS07885 Protein ID WP_002886901.1
Coordinates 1601396..1601638 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU074_RS07860 1596539..1596847 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CU074_RS29630 1596932..1597105 + 174 WP_032433782.1 hypothetical protein -
CU074_RS07865 1597108..1597851 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CU074_RS07870 1598208..1600346 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
CU074_RS07875 1600654..1601118 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CU074_RS07880 1601122..1601406 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CU074_RS07885 1601396..1601638 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CU074_RS07890 1601716..1603626 - 1911 WP_009486549.1 BglG family transcription antiterminator -
CU074_RS07895 1603649..1604803 - 1155 WP_002886900.1 lactonase family protein -
CU074_RS07900 1604870..1605610 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T88772 WP_009486548.1 NZ_CP024838:c1601406-1601122 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T88772 NZ_CP024838:c1601406-1601122 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT88772 WP_002886901.1 NZ_CP024838:c1601638-1601396 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT88772 NZ_CP024838:c1601638-1601396 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References