Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4963089..4963920 Replicon chromosome
Accession NZ_CP024821
Organism Escherichia coli strain CREC-591

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag CU078_RS25825 Protein ID WP_000854814.1
Coordinates 4963089..4963463 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag CU078_RS25830 Protein ID WP_001285585.1
Coordinates 4963552..4963920 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU078_RS25790 4958485..4959651 + 1167 WP_001464461.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
CU078_RS25795 4959770..4960243 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
CU078_RS25800 4960441..4961499 + 1059 WP_072646463.1 FUSC family protein -
CU078_RS25805 4961671..4962000 + 330 WP_000450409.1 DUF496 family protein -
CU078_RS25810 4962101..4962283 - 183 WP_001016348.1 hypothetical protein -
CU078_RS25815 4962355..4962483 + 129 Protein_4697 transposase domain-containing protein -
CU078_RS29190 4962772..4962885 - 114 WP_001161660.1 DUF957 domain-containing protein -
CU078_RS25820 4962898..4963092 - 195 WP_000988600.1 hypothetical protein -
CU078_RS25825 4963089..4963463 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
CU078_RS25830 4963552..4963920 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CU078_RS25835 4963994..4964215 - 222 WP_000692323.1 DUF987 domain-containing protein -
CU078_RS25840 4964278..4964754 - 477 WP_001186773.1 RadC family protein -
CU078_RS25845 4964770..4965249 - 480 WP_000860076.1 antirestriction protein -
CU078_RS25850 4965331..4966152 - 822 WP_001234530.1 DUF945 domain-containing protein -
CU078_RS25860 4966373..4966783 - 411 WP_000846713.1 hypothetical protein -
CU078_RS25865 4966799..4967482 - 684 WP_001514307.1 hypothetical protein -
CU078_RS25870 4967618..4968688 - 1071 WP_000102624.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T88659 WP_000854814.1 NZ_CP024821:c4963463-4963089 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T88659 NZ_CP024821:c4963463-4963089 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT88659 WP_001285585.1 NZ_CP024821:c4963920-4963552 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT88659 NZ_CP024821:c4963920-4963552 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References