Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2551945..2552776 Replicon chromosome
Accession NZ_CP024815
Organism Escherichia coli strain CREC-629

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag CU080_RS12905 Protein ID WP_000854814.1
Coordinates 2551945..2552319 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag CU080_RS12910 Protein ID WP_001285585.1
Coordinates 2552408..2552776 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU080_RS12870 2547341..2548507 + 1167 WP_000830163.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
CU080_RS12875 2548626..2549099 + 474 WP_001105393.1 DNA gyrase inhibitor SbmC -
CU080_RS12880 2549297..2550355 + 1059 WP_001200905.1 FUSC family protein -
CU080_RS12885 2550527..2550856 + 330 WP_000450409.1 DUF496 family protein -
CU080_RS12890 2550957..2551139 - 183 WP_001016348.1 hypothetical protein -
CU080_RS12895 2551193..2551339 + 147 Protein_2342 transposase domain-containing protein -
CU080_RS27915 2551628..2551741 - 114 WP_001161660.1 DUF957 domain-containing protein -
CU080_RS12900 2551754..2551948 - 195 WP_000988600.1 hypothetical protein -
CU080_RS12905 2551945..2552319 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
CU080_RS12910 2552408..2552776 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CU080_RS12915 2552850..2553071 - 222 WP_000692323.1 DUF987 domain-containing protein -
CU080_RS12920 2553134..2553610 - 477 WP_001186773.1 RadC family protein -
CU080_RS12925 2553626..2554105 - 480 WP_000860076.1 antirestriction protein -
CU080_RS12930 2554187..2555008 - 822 WP_001234530.1 DUF945 domain-containing protein -
CU080_RS12940 2555229..2555639 - 411 WP_000846713.1 hypothetical protein -
CU080_RS12945 2555655..2556338 - 684 WP_000775500.1 hypothetical protein -
CU080_RS12950 2556474..2557544 - 1071 WP_000102643.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T88590 WP_000854814.1 NZ_CP024815:c2552319-2551945 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T88590 NZ_CP024815:c2552319-2551945 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT88590 WP_001285585.1 NZ_CP024815:c2552776-2552408 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT88590 NZ_CP024815:c2552776-2552408 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References