Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1504296..1505127 Replicon chromosome
Accession NZ_CP024720
Organism Escherichia coli isolate NQ3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag CUB98_RS07575 Protein ID WP_000854815.1
Coordinates 1504296..1504670 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag CUB98_RS07580 Protein ID WP_001280918.1
Coordinates 1504759..1505127 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUB98_RS07540 1499692..1500858 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
CUB98_RS07545 1500977..1501450 + 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
CUB98_RS07550 1501648..1502706 + 1059 WP_099996231.1 FUSC family protein -
CUB98_RS07555 1502878..1503207 + 330 WP_000450409.1 DUF496 family protein -
CUB98_RS07560 1503308..1503490 - 183 WP_001296208.1 hypothetical protein -
CUB98_RS07565 1503544..1503690 + 147 Protein_1390 transposase domain-containing protein -
CUB98_RS27880 1503979..1504092 - 114 WP_001161660.1 DUF957 domain-containing protein -
CUB98_RS07570 1504105..1504299 - 195 WP_000988600.1 hypothetical protein -
CUB98_RS07575 1504296..1504670 - 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
CUB98_RS07580 1504759..1505127 - 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CUB98_RS07585 1505143..1505787 - 645 WP_000086752.1 hypothetical protein -
CUB98_RS07590 1505806..1506027 - 222 WP_000692345.1 DUF987 domain-containing protein -
CUB98_RS07595 1506090..1506566 - 477 WP_001186200.1 RadC family protein -
CUB98_RS07600 1506582..1507055 - 474 WP_001542276.1 antirestriction protein -
CUB98_RS07605 1507149..1507394 - 246 WP_001164966.1 hypothetical protein -
CUB98_RS07610 1507394..1508212 - 819 WP_001542275.1 DUF945 domain-containing protein -
CUB98_RS07620 1508433..1508843 - 411 WP_000846703.1 hypothetical protein -
CUB98_RS07625 1508859..1509209 - 351 Protein_1402 hypothetical protein -
CUB98_RS07635 1509292..1510038 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T88465 WP_000854815.1 NZ_CP024720:c1504670-1504296 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T88465 NZ_CP024720:c1504670-1504296 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT88465 WP_001280918.1 NZ_CP024720:c1505127-1504759 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT88465 NZ_CP024720:c1505127-1504759 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References