Detailed information of TA system TA088386

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 731051..731729
• Replicon: chromosome
• Accession: NZ_CP024710
• Organism: Dickeya solani strain IFB0223

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: CTB91_RS03505
• Protein ID: WP_023637601.1
• Coordinates: 731298..731729 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2K8QSU7
• Locus tag: CTB91_RS03500
• Protein ID: WP_023637600.1
• Coordinates: 731051..731317 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CTB91_RS03480	727501..728151	+	651	WP_022632163.1	LysE family translocator	-
CTB91_RS03485	728222..728830	-	609	WP_022632164.1	HD domain-containing protein	-
CTB91_RS03490	729040..729690	+	651	WP_022632165.1	hemolysin III family protein	-
CTB91_RS03495	729764..730744	-	981	WP_022632166.1	tRNA-modifying protein YgfZ	-
CTB91_RS03500	731051..731317	+	267	WP_023637600.1	FAD assembly factor SdhE	Antitoxin
CTB91_RS03505	731298..731729	+	432	WP_023637601.1	protein YgfX	Toxin
CTB91_RS03510	731829..732347	-	519	WP_022632169.1	flavodoxin FldB	-
CTB91_RS03515	732476..733801	-	1326	WP_022632170.1	MHS family MFS transporter	-
CTB91_RS03520	734064..734963	+	900	WP_022632171.1	site-specific tyrosine recombinase XerD	-
CTB91_RS03525	735053..735760	+	708	WP_022632172.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16808.51 Da
• Isoelectric Point: 11.7737

>T88386 WP_023637601.1 NZ_CP024710:731298-731729 [Dickeya solani]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T88386 NZ_CP024710:731298-731729 [Dickeya solani]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGTTGTTTTCGCTGCTGACGCACGGGTTTCTGGTGCT
GATGATCCTGCTGGCGCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATTAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAGCAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACTGGCAAAGGGCA
TCAGCGTCTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAGTGGCGGCTGTTGCGCCAGCTGTTGCAGCAGCACCCGC
TGCAGGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.03 Da
• Isoelectric Point: 5.5535

>AT88386 WP_023637600.1 NZ_CP024710:731051-731317 [Dickeya solani]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT88386 NZ_CP024710:731051-731317 [Dickeya solani]
ATGGACATCAATAACAAATCACGTATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCATGGCGAGCCGGTGGATCCGGAGCTGAAACGTATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K8QSU7