Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1771125..1771764 Replicon chromosome
Accession NZ_CP024675
Organism Citrobacter werkmanii strain UMH18

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CUC50_RS08650 Protein ID WP_085048165.1
Coordinates 1771588..1771764 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CUC50_RS08645 Protein ID WP_153070622.1
Coordinates 1771125..1771541 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUC50_RS08625 1766170..1767114 - 945 WP_121529077.1 ABC transporter permease -
CUC50_RS08630 1767115..1768131 - 1017 WP_121529078.1 ABC transporter ATP-binding protein -
CUC50_RS08635 1768148..1769293 - 1146 WP_069324934.1 ABC transporter substrate-binding protein -
CUC50_RS08640 1769623..1771032 - 1410 WP_121529079.1 PLP-dependent aminotransferase family protein -
CUC50_RS08645 1771125..1771541 - 417 WP_153070622.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CUC50_RS08650 1771588..1771764 - 177 WP_085048165.1 type II toxin-antitoxin system HicA family toxin Toxin
CUC50_RS08655 1772029..1773432 + 1404 WP_085048164.1 cytochrome ubiquinol oxidase subunit I -
CUC50_RS08660 1773432..1774442 + 1011 WP_087856574.1 cytochrome d ubiquinol oxidase subunit II -
CUC50_RS08665 1774442..1774567 + 126 WP_064507023.1 DUF2474 domain-containing protein -
CUC50_RS08670 1774757..1774987 + 231 WP_038640744.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6783.83 Da        Isoelectric Point: 11.6208

>T88249 WP_085048165.1 NZ_CP024675:c1771764-1771588 [Citrobacter werkmanii]
VKQSEFRRWLESQGVKVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIQKQLGLQ

Download         Length: 177 bp

>T88249 NZ_CP024675:c1771764-1771588 [Citrobacter werkmanii]
GTGAAGCAAAGTGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTTAAAGTTACAAACGGCTCAAATCATCTGAAGTTGAG
GTATCAGGGAAGGCGTAGCGTTATGCCCAGGCATCCTGGTGATGAGATAAAAGAGGCCCTGCGAAAAGCGATCCAAAAGC
AGCTTGGCTTACAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15050.32 Da        Isoelectric Point: 4.5468

>AT88249 WP_153070622.1 NZ_CP024675:c1771541-1771125 [Citrobacter werkmanii]
MRYPVNLIPAVEGGFMVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVSML

Download         Length: 417 bp

>AT88249 NZ_CP024675:c1771541-1771125 [Citrobacter werkmanii]
ATGCGTTATCCCGTTAATCTAATACCCGCCGTGGAAGGTGGGTTCATGGTGTCTTTTCCGGATATTCCTGAAGCATTGAC
TCAGGGAGAAACTCGCCATGATGCTTTGCAGGCTGCGCAGGCCGCATTGGTCACCGCTTTTGAATTCTATTTCGACGATA
ACGAACCGATTCCTTTGCCTTCAGCGGTTGTCGCTGGCGCTGACTATGTGGAAATACCACTGAGCGTTGCGTCTAAGGTT
CTGTTGTTAAATGCCTTCCTTGAATCGAATATTACCCAGCAGGAGTTGGCAAACAGGATCGGCAGGCCTAAGCAGGAAAT
CACCCGTTTATTCGATTTAAAGCACGCGACAAAAATTGATGCTGTGCAGATAGCTGCCCGCGCTTTAGGAAAAGAACTGT
CGGTATCGATGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References