Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1706713..1708349 Replicon chromosome
Accession NZ_CP024632
Organism Acinetobacter junii strain lzh-X15

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CS557_RS08135 Protein ID WP_099948676.1
Coordinates 1706713..1708044 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CS557_RS08140 Protein ID WP_099948677.1
Coordinates 1708041..1708349 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS557_RS08110 1702110..1703105 + 996 WP_004954402.1 DUF1852 domain-containing protein -
CS557_RS08115 1703129..1704157 + 1029 WP_004911103.1 methionine synthase -
CS557_RS08120 1704344..1704838 + 495 WP_099948674.1 flavin reductase -
CS557_RS08125 1704880..1705677 + 798 WP_039907982.1 sulfite exporter TauE/SafE family protein -
CS557_RS08130 1705737..1706435 - 699 WP_099948675.1 DUF1826 domain-containing protein -
CS557_RS08135 1706713..1708044 + 1332 WP_099948676.1 HipA domain-containing protein Toxin
CS557_RS08140 1708041..1708349 + 309 WP_099948677.1 helix-turn-helix domain-containing protein Antitoxin
CS557_RS08145 1708428..1708670 - 243 WP_099949501.1 VF530 family protein -
CS557_RS08150 1709091..1709339 + 249 WP_099949502.1 hypothetical protein -
CS557_RS08155 1709557..1710707 + 1151 WP_099948678.1 IS3 family transposase -
CS557_RS08160 1710725..1710949 - 225 Protein_1572 DUF4158 domain-containing protein -
CS557_RS08165 1711075..1712226 - 1152 WP_099948679.1 acyl-CoA dehydrogenase family protein -
CS557_RS08170 1712263..1712712 - 450 WP_099948680.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1679215..1745614 66399


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-365)

Antitoxin

Cro/C1-type helix-turn-helix domain

(29-82)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50818.59 Da        Isoelectric Point: 4.7802

>T88117 WP_099948676.1 NZ_CP024632:1706713-1708044 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASVSELVYELEYAIQNLDKRDEHACSLSLPVQILINHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTYAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRYGLESVYSILNKASGSYLNHFEVIENLCNLLISIDSEFDSAQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQFGKISLAPIYDFAPMKADPEVITRSTTWGSPYEEGGEYRWEQITQKLAHLCDPNLSLSTLK
SLASHLVGLKQRLIDKGVPKQIVEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

>T88117 NZ_CP024632:1706713-1708044 [Acinetobacter junii]
ATGAAAAAACTAACAATACAGGCGTTACTTGATCAAAGTTGGTTTGATATTGCTGAACTAACATTATTAGAACCTAAACT
AGGCTCAGCAAGTGTCAGTGAATTGGTCTACGAGTTAGAATACGCAATCCAAAATCTGGACAAGCGAGATGAACATGCAT
GTAGTCTCTCACTTCCTGTACAAATACTTATAAACCATGAATCTAGCTCATGGTTTGGTTTTTTGGATGATATTGTTCCT
TCAGGTGCAGCACGCCGTTATTGGGTCAATTTTTTAGGCTTACAACGGCTCACTTATGCTGAGCAAGATAGTATTTTATT
AGAAAAAGGTGGCATCGCACCCGTAGGCAATTTGAGAATTAAAGAAGCTCTTCCACCAATCAATCCTGAATCGACTCTGC
ATTTACGTTATTTTAGTCAAAGTGATGTTGCTGACCGAAATGTAGATTTTCTTGAATATGCACAGCAAATGGGTGCAATT
AGTGGTGGTGCAACAGGAGCGGGTGGTGAAGCTCCTAAATTATTGATTCGTGCTACAAAAGATCAAAATATTTGGATTGA
TACTTATCAACAAAACTTTGATCAACCTGATCAACATTATCTAGTTAAATTCCCTAGAAATAATCGTAGTGAGATCGACT
GTAATATTCTCAGAGCAGAATACTATTACTATCAAGAGCTAAAAGAGTTGGGTTTCAATACCATTGAAACTACAGAAATG
AAGCTGATAGAAGGTGAAAAATATCCATCATTATGGCTACCAAGATTTGATGTCGAATGGCACAACCAAAAATGGCATCG
TTATGGACTTGAATCTGTCTATTCCATATTAAATAAAGCTTCAGGTAGCTATCTCAATCACTTTGAAGTGATTGAGAATC
TATGCAATTTACTGATATCTATTGATTCAGAGTTTGATTCAGCACAATTCGTTTGTGAGTGGTTACAGCGAGATTTACTC
AATATTATTTTTGGTAATTCTGATAATCATGGGCGAAATACTTCATTTCTAAAACAATTTGGAAAAATTTCGCTTGCTCC
AATTTATGATTTTGCTCCAATGAAAGCTGATCCAGAAGTTATTACAAGATCAACAACTTGGGGAAGTCCTTATGAGGAAG
GAGGAGAATATCGATGGGAGCAAATTACCCAAAAGCTAGCACATTTATGCGATCCGAATTTGTCTCTATCTACATTGAAA
TCTTTAGCAAGTCATCTTGTTGGGCTAAAACAAAGATTAATAGATAAAGGTGTACCAAAACAAATTGTGGAGATGCCAGC
GCTTTCATTCGACTATGTTGAAGCTAAATTAGAAAGATGGGAACTATTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11706.72 Da        Isoelectric Point: 10.1562

>AT88117 WP_099948677.1 NZ_CP024632:1708041-1708349 [Acinetobacter junii]
MNTKKQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp

>AT88117 NZ_CP024632:1708041-1708349 [Acinetobacter junii]
ATGAATACAAAAAAACAGACTCAAGATCGTCAACAAGTTCTTATTGATCTATATATGCAGTACTTATTGAATGAAATCAC
ATTGGGGCAATTATTGGCGTATTTGCGAAAAAATATTCTTGGTATGTCTCAGGAACAATATGCAAATTTAGTCGGTGTAA
GTCGTAGGACGTTAACTGATATTGAACAAGATAAAGGAAAACTTACTCAATCTGTTTTAGACAAGGTATTTAAACCACTT
GGATTGAAAGCAGGACTTGTACCGACTCATGAGCACATTGTGAGAAAGATCATTAAACCATCAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References