Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1451757..1452552 Replicon chromosome
Accession NZ_CP024618
Organism Escherichia coli strain SMN152SH1

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag CR916_RS08790 Protein ID WP_000854914.1
Coordinates 1452178..1452552 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag CR916_RS08785 Protein ID WP_001280954.1
Coordinates 1451757..1452131 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CR916_RS08745 1447113..1448018 + 906 WP_000203541.1 chemotaxis protein -
CR916_RS08750 1448015..1449084 + 1070 Protein_1426 patatin-like phospholipase family protein -
CR916_RS08765 1449424..1450242 + 819 WP_001234682.1 DUF945 domain-containing protein -
CR916_RS08770 1450333..1450818 + 486 WP_000214398.1 antirestriction protein -
CR916_RS08775 1450834..1451310 + 477 WP_062882313.1 RadC family protein -
CR916_RS08780 1451373..1451594 + 222 WP_001220314.1 DUF987 domain-containing protein -
CR916_RS08785 1451757..1452131 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CR916_RS08790 1452178..1452552 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
CR916_RS08795 1452549..1453040 + 492 WP_000976857.1 hypothetical protein -
CR916_RS08800 1453052..1453249 + 198 WP_000839282.1 DUF957 domain-containing protein -
CR916_RS08805 1453334..1454176 + 843 WP_001280481.1 DUF4942 domain-containing protein -
CR916_RS08815 1454667..1454885 - 219 WP_001040187.1 translation initiation factor IF-1 -
CR916_RS08820 1455170..1455874 - 705 WP_062882312.1 leucyl/phenylalanyl-tRNA--protein transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T88071 WP_000854914.1 NZ_CP024618:1452178-1452552 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T88071 NZ_CP024618:1452178-1452552 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT88071 WP_001280954.1 NZ_CP024618:1451757-1452131 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT88071 NZ_CP024618:1451757-1452131 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References