Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2147430..2148265 Replicon chromosome
Accession NZ_CP024232
Organism Escherichia coli O6:H16 strain 2014EL-1346-6

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CNZ63_RS11140 Protein ID WP_000854743.1
Coordinates 2147430..2147807 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag CNZ63_RS11145 Protein ID WP_001285298.1
Coordinates 2147897..2148265 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNZ63_RS11105 2142788..2143711 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
CNZ63_RS11110 2143822..2145006 - 1185 WP_001172882.1 sugar efflux transporter -
CNZ63_RS11125 2145801..2146639 - 839 Protein_1990 DUF4942 domain-containing protein -
CNZ63_RS11130 2146736..2146933 - 198 WP_000839275.1 DUF957 domain-containing protein -
CNZ63_RS11135 2146945..2147433 - 489 WP_000761693.1 hypothetical protein -
CNZ63_RS11140 2147430..2147807 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
CNZ63_RS11145 2147897..2148265 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CNZ63_RS11150 2148315..2148959 - 645 WP_000086754.1 hypothetical protein -
CNZ63_RS11155 2148978..2149199 - 222 WP_000692307.1 DUF987 domain-containing protein -
CNZ63_RS11160 2149262..2149738 - 477 WP_001186774.1 RadC family protein -
CNZ63_RS11165 2149753..2150238 - 486 WP_000206659.1 antirestriction protein -
CNZ63_RS11170 2150330..2151151 - 822 WP_001706654.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T87150 WP_000854743.1 NZ_CP024232:c2147807-2147430 [Escherichia coli O6:H16]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T87150 NZ_CP024232:c2147807-2147430 [Escherichia coli O6:H16]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATTCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
GGTGCCTGTACCTATTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT87150 WP_001285298.1 NZ_CP024232:c2148265-2147897 [Escherichia coli O6:H16]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp

>AT87150 NZ_CP024232:c2148265-2147897 [Escherichia coli O6:H16]
ATGTCAGACTCGCGCCATGAGACAAATTATCCCGACGACCATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAT
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTGCGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References