Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1945664..1946496 | Replicon | chromosome |
| Accession | NZ_CP024155 | ||
| Organism | Escherichia coli strain 14EC047 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | CR540_RS09720 | Protein ID | WP_134894847.1 |
| Coordinates | 1945664..1946038 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | E3PJ72 |
| Locus tag | CR540_RS09725 | Protein ID | WP_001278232.1 |
| Coordinates | 1946128..1946496 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CR540_RS09680 (1941075) | 1941075..1942241 | + | 1167 | WP_001296209.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| CR540_RS09685 (1942360) | 1942360..1942833 | + | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| CR540_RS09690 (1943031) | 1943031..1944089 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| CR540_RS09695 (1944261) | 1944261..1944590 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| CR540_RS27560 (1944691) | 1944691..1945014 | - | 324 | WP_249929342.1 | EutP/PduV family microcompartment system protein | - |
| CR540_RS27565 (1944993) | 1944993..1945073 | + | 81 | WP_023441679.1 | hypothetical protein | - |
| CR540_RS09710 (1945362) | 1945362..1945442 | - | 81 | Protein_1879 | hypothetical protein | - |
| CR540_RS09715 (1945488) | 1945488..1945667 | - | 180 | WP_134894846.1 | DUF5983 family protein | - |
| CR540_RS09720 (1945664) | 1945664..1946038 | - | 375 | WP_134894847.1 | TA system toxin CbtA family protein | Toxin |
| CR540_RS09725 (1946128) | 1946128..1946496 | - | 369 | WP_001278232.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| CR540_RS09730 (1946576) | 1946576..1946797 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| CR540_RS09735 (1946866) | 1946866..1947342 | - | 477 | WP_001186771.1 | RadC family protein | - |
| CR540_RS09740 (1947358) | 1947358..1947843 | - | 486 | WP_134894848.1 | antirestriction protein | - |
| CR540_RS09745 (1947934) | 1947934..1948752 | - | 819 | WP_134894849.1 | DUF932 domain-containing protein | - |
| CR540_RS09755 (1948852) | 1948852..1949085 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| CR540_RS09760 (1949164) | 1949164..1949619 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13893.86 Da Isoelectric Point: 7.8045
>T86992 WP_134894847.1 NZ_CP024155:c1946038-1945664 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T86992 NZ_CP024155:c1946038-1945664 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGAGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
ATGAAAACATTACCCGATACACACGTACGAGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13491.37 Da Isoelectric Point: 6.6290
>AT86992 WP_001278232.1 NZ_CP024155:c1946496-1946128 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT86992 NZ_CP024155:c1946496-1946128 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|