Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2634834..2635573 Replicon chromosome
Accession NZ_CP023963
Organism Klebsiella aerogenes strain FDAARGOS_363

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag CRN78_RS12965 Protein ID WP_015705365.1
Coordinates 2634834..2635319 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag CRN78_RS12970 Protein ID WP_015705366.1
Coordinates 2635307..2635573 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN78_RS12945 2630381..2631451 - 1071 WP_046883609.1 mannonate dehydratase -
CRN78_RS12950 2631712..2631870 + 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
CRN78_RS12955 2631927..2633027 - 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
CRN78_RS12960 2633146..2634762 - 1617 WP_042897505.1 FAD-NAD(P)-binding protein -
CRN78_RS12965 2634834..2635319 - 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
CRN78_RS12970 2635307..2635573 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
CRN78_RS12975 2635846..2637081 + 1236 WP_032711619.1 MFS transporter -
CRN78_RS12980 2637125..2637622 - 498 WP_032711620.1 heme-binding protein -
CRN78_RS12985 2637718..2638335 - 618 WP_032705773.1 response regulator transcription factor -
CRN78_RS12990 2638335..2639654 - 1320 WP_086557325.1 two-component sensor histidine kinase -
CRN78_RS12995 2639651..2640238 - 588 WP_042897498.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T86510 WP_015705365.1 NZ_CP023963:c2635319-2634834 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T86510 NZ_CP023963:c2635319-2634834 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCTCAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTATCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTCTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTTCGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT86510 WP_015705366.1 NZ_CP023963:c2635573-2635307 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT86510 NZ_CP023963:c2635573-2635307 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGACAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References