Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 429019..429638 Replicon chromosome
Accession NZ_CP023962
Organism Yersinia frederiksenii strain FDAARGOS_417

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag CRN74_RS01855 Protein ID WP_002208622.1
Coordinates 429019..429222 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9UMX9
Locus tag CRN74_RS01860 Protein ID WP_019212878.1
Coordinates 429270..429638 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRN74_RS01845 424685..425107 - 423 WP_050082618.1 hypothetical protein -
CRN74_RS01850 425796..428306 + 2511 WP_098905214.1 autotransporter outer membrane beta-barrel domain-containing protein -
CRN74_RS01855 429019..429222 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
CRN74_RS01860 429270..429638 - 369 WP_019212878.1 Hha toxicity modulator TomB Antitoxin
CRN74_RS01865 429797..430150 - 354 WP_050873616.1 hypothetical protein -
CRN74_RS01870 430936..431673 + 738 WP_050286523.1 ATP-binding cassette domain-containing protein -
CRN74_RS01875 431670..432527 + 858 WP_098904254.1 metal ABC transporter permease -
CRN74_RS01880 432556..433434 + 879 WP_050873615.1 metal ABC transporter substrate-binding protein -
CRN74_RS01885 433517..433660 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
CRN74_RS01890 433676..433936 - 261 WP_050082629.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T86491 WP_002208622.1 NZ_CP023962:c429222-429019 [Yersinia frederiksenii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T86491 NZ_CP023962:c429222-429019 [Yersinia frederiksenii]
ATGACTAAAACTGACTACCTGATGCGTTTAAGAAAGTGTACGACTATTGACACGCTTGAGCGTGTAATTGAAAAAAATAA
ATATGAACTTTCTGACGATGAGTTGGAGTTATTCTACTCAGCAGCCGATCATCGCTTAGCTGAGCTCACAATGAATAAGC
TTTATGATAAAATTCCACCTACAGTTTGGCAGCATGTAAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14204.96 Da        Isoelectric Point: 4.4314

>AT86491 WP_019212878.1 NZ_CP023962:c429638-429270 [Yersinia frederiksenii]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTAAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKS

Download         Length: 369 bp

>AT86491 NZ_CP023962:c429638-429270 [Yersinia frederiksenii]
ATGGATGAGTACTCGCCAAAAAGGCATGATATTGCCCAACTGAAGTTTCTCTGTGAGAGTTTGTATGATGAAGGTATTGC
TACGCTCGGCGATAGCCATCATGGGTGGGTGAACGACCCCACAGCAGCTGTCAATCTGCAACTTAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGACGACGGCGACCTATCAGAGCTAGTGGAAGAATATTTA
GACGATACTTATACTCTGTTTAGTAGTTACGGGATCAACGATCCCGAATTGCGTCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACGCTGATGAAAAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UMX9

References