Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 160030..160283 | Replicon | plasmid unnamed2 |
Accession | NZ_CP023942 | ||
Organism | Klebsiella pneumoniae strain FDAARGOS_444 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | G9G1E3 |
Locus tag | CRN70_RS28980 | Protein ID | WP_001312851.1 |
Coordinates | 160030..160179 (-) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 160224..160283 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CRN70_RS28935 | 155389..155804 | - | 416 | Protein_199 | IS1 family transposase | - |
CRN70_RS28945 | 156053..156454 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
CRN70_RS30810 | 156387..156644 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
CRN70_RS28950 | 156737..157390 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
CRN70_RS28960 | 158329..159186 | - | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
CRN70_RS28965 | 159179..159253 | - | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
CRN70_RS28975 | 159498..159746 | - | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
CRN70_RS28980 | 160030..160179 | - | 150 | WP_001312851.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
- | 160224..160283 | + | 60 | NuclAT_1 | - | Antitoxin |
- | 160224..160283 | + | 60 | NuclAT_1 | - | Antitoxin |
- | 160224..160283 | + | 60 | NuclAT_1 | - | Antitoxin |
- | 160224..160283 | + | 60 | NuclAT_1 | - | Antitoxin |
CRN70_RS28990 | 160484..160714 | - | 231 | WP_001736714.1 | hypothetical protein | - |
CRN70_RS28995 | 160878..161477 | - | 600 | WP_032083981.1 | hypothetical protein | - |
CRN70_RS29000 | 161863..162063 | - | 201 | WP_015059022.1 | hypothetical protein | - |
CRN70_RS29005 | 162195..162755 | - | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
CRN70_RS29010 | 162810..163556 | - | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
CRN70_RS29015 | 163576..163737 | - | 162 | Protein_212 | DNA helicase | - |
CRN70_RS29020 | 163801..164505 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
CRN70_RS29025 | 164558..164623 | + | 66 | Protein_214 | helix-turn-helix domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | floR / catA2 / blaKPC-2 / rmtB / blaTEM-1B / blaCTX-M-65 | - | 1..187926 | 187926 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T86401 WP_001312851.1 NZ_CP023942:c160179-160030 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T86401 NZ_CP023942:c160179-160030 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 60 bp
>AT86401 NZ_CP023942:160224-160283 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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