Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2989514..2990079 Replicon chromosome
Accession NZ_CP023747
Organism Streptomyces nodosus strain ATCC 14899

Toxin (Protein)


Gene name doc Uniprot ID A0A0B5DKC0
Locus tag CP978_RS13580 Protein ID WP_043440629.1
Coordinates 2989514..2989882 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0B5DLL9
Locus tag CP978_RS13585 Protein ID WP_043440632.1
Coordinates 2989882..2990079 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP978_RS13555 2984849..2985430 + 582 WP_043448549.1 helix-turn-helix domain-containing protein -
CP978_RS13560 2985443..2985625 + 183 WP_043440619.1 hypothetical protein -
CP978_RS13565 2985693..2986484 - 792 WP_043440622.1 hypothetical protein -
CP978_RS13570 2986576..2987217 - 642 WP_043440625.1 helix-turn-helix domain-containing protein -
CP978_RS13575 2987584..2989377 - 1794 WP_043440627.1 DEAD/DEAH box helicase -
CP978_RS13580 2989514..2989882 - 369 WP_043440629.1 Fic family protein Toxin
CP978_RS13585 2989882..2990079 - 198 WP_043440632.1 hypothetical protein Antitoxin
CP978_RS13590 2990112..2991569 - 1458 WP_043440634.1 MFS transporter -
CP978_RS13600 2991881..2992954 - 1074 WP_052454104.1 SUKH-4 family immunity protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(12-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13664.57 Da        Isoelectric Point: 5.1244

>T85991 WP_043440629.1 NZ_CP023747:c2989882-2989514 [Streptomyces nodosus]
MYHLTLPELLNLAQRLGADEVRDFGLLDSALARPRSSVFGQDAYPDVWQKAAALMESLARNHALVDGNKRIAWYATWVFL
HMNGHPLDSGFDVDEAERFVLDVCQGALDVPKIAARLPEFAR

Download         Length: 369 bp

>T85991 NZ_CP023747:c2989882-2989514 [Streptomyces nodosus]
ATGTATCACCTCACGCTTCCCGAGCTGCTGAACCTTGCGCAGCGGCTCGGTGCGGACGAGGTTCGCGACTTCGGGCTTCT
GGACTCGGCGCTGGCGCGCCCCCGGTCGAGCGTCTTCGGGCAGGACGCCTATCCGGACGTCTGGCAGAAGGCCGCGGCGC
TGATGGAGTCCCTGGCCCGCAACCATGCCCTCGTCGACGGAAACAAGCGCATCGCCTGGTACGCGACCTGGGTCTTTCTG
CATATGAACGGGCATCCGCTCGACTCCGGCTTCGATGTGGACGAGGCCGAGCGATTCGTCCTGGACGTGTGTCAGGGTGC
CCTGGATGTGCCCAAGATCGCGGCCCGGTTGCCTGAGTTCGCGCGCTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7174.02 Da        Isoelectric Point: 5.0372

>AT85991 WP_043440632.1 NZ_CP023747:c2990079-2989882 [Streptomyces nodosus]
MAGLNVRFTDEELDALRERAAAEGRSMQAFAHEAVIAAINEHARLFNEAAEHVLQASAELNRRLA

Download         Length: 198 bp

>AT85991 NZ_CP023747:c2990079-2989882 [Streptomyces nodosus]
ATGGCTGGACTGAATGTGCGTTTCACGGACGAAGAGCTCGACGCGCTGCGCGAGCGTGCGGCGGCGGAAGGGCGCAGCAT
GCAGGCCTTCGCACACGAGGCCGTGATCGCGGCCATAAACGAGCACGCGAGGCTGTTCAACGAGGCGGCGGAGCATGTGC
TGCAGGCCAGCGCCGAGCTGAACCGAAGGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5DKC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0B5DLL9

References