Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4080031..4080665 Replicon chromosome
Accession NZ_CP023693
Organism Streptomyces cinereoruber strain ATCC 19740

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CP977_RS18240 Protein ID WP_152370482.1
Coordinates 4080031..4080453 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CP977_RS18245 Protein ID WP_109186718.1
Coordinates 4080450..4080665 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP977_RS18220 4075536..4077791 - 2256 WP_152370480.1 FtsX-like permease family protein -
CP977_RS18225 4077788..4078462 - 675 WP_062753550.1 ABC transporter ATP-binding protein -
CP977_RS18230 4078521..4078934 - 414 WP_152371589.1 hypothetical protein -
CP977_RS18235 4079476..4079673 + 198 WP_152370481.1 hypothetical protein -
CP977_RS18240 4080031..4080453 - 423 WP_152370482.1 PIN domain nuclease Toxin
CP977_RS18245 4080450..4080665 - 216 WP_109186718.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CP977_RS18250 4080731..4083153 - 2423 Protein_3562 helicase-associated domain-containing protein -
CP977_RS18255 4083862..4084497 - 636 WP_152370483.1 DUF4276 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15342.30 Da        Isoelectric Point: 5.5883

>T85908 WP_152370482.1 NZ_CP023693:c4080453-4080031 [Streptomyces cinereoruber]
VNAALYLIDTSALARFMRGDAEQYGWDQAAAAGLIATSPITELEFFHSARSAADRARGIEDIRLLFGWVPVDDRAYDRAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHCDHDFECIAAVTGQPLQWYGPKGRK

Download         Length: 423 bp

>T85908 NZ_CP023693:c4080453-4080031 [Streptomyces cinereoruber]
GTGAACGCCGCGCTCTACCTGATCGACACCAGCGCCCTCGCCCGATTCATGCGGGGCGACGCGGAACAGTACGGCTGGGA
TCAGGCAGCGGCCGCCGGCCTGATCGCCACAAGCCCCATCACGGAGCTGGAGTTCTTCCACAGCGCCCGATCGGCCGCCG
ACCGGGCACGCGGCATCGAGGACATAAGGCTGCTCTTCGGTTGGGTCCCCGTCGACGACCGCGCTTACGACCGGGCCTGG
CAGGTCCAGGAGGCCCTCACCAAGCAAGGCAAGCACCGCAGCGCAGGCGCAGTCGATCTCGTTGTCGCAGCGACTGCCGA
GCTGCAGGGGCTCACCCTCCTGCACTGTGACCACGACTTCGAATGCATCGCCGCAGTAACCGGCCAGCCCCTCCAGTGGT
ACGGCCCGAAGGGCCGTAAGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8017.12 Da        Isoelectric Point: 8.6590

>AT85908 WP_109186718.1 NZ_CP023693:c4080665-4080450 [Streptomyces cinereoruber]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGAFDLTLLEDKRNYRR

Download         Length: 216 bp

>AT85908 NZ_CP023693:c4080665-4080450 [Streptomyces cinereoruber]
ATGAGCCGGACAGTGATCGACCTCGATGACGAGCTGGTGGCAGACGTAGCCAAAGCCCTGGGCACCAGCACCAAGAAGGA
GACGGTCAACACAGCCTTGCGCGAGGTACTGGAGAACAGGCGGCGGGCACTGGCCCTGACCCGCCTGCGCGCCGCGGCCG
ACGAAGGCGCGTTCGATCTGACGCTTCTCGAGGACAAGCGGAACTACCGACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References