Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 2458894..2459546 Replicon chromosome
Accession NZ_CP023656
Organism Halomonas hydrothermalis strain Y2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CLM76_RS11560 Protein ID WP_039176369.1
Coordinates 2458894..2459145 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CLM76_RS11565 Protein ID WP_039176367.1
Coordinates 2459184..2459546 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM76_RS11540 2455978..2456328 + 351 WP_157779972.1 hypothetical protein -
CLM76_RS11545 2456535..2457935 + 1401 WP_157779973.1 hypothetical protein -
CLM76_RS11550 2457932..2458486 - 555 WP_096922575.1 phage tail protein I -
CLM76_RS11555 2458483..2458806 - 324 WP_096922576.1 baseplate J/gp47 family protein -
CLM76_RS11560 2458894..2459145 + 252 WP_039176369.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CLM76_RS11565 2459184..2459546 + 363 WP_039176367.1 helix-turn-helix transcriptional regulator Antitoxin
CLM76_RS18295 2459628..2459963 - 336 WP_152607569.1 hypothetical protein -
CLM76_RS11570 2459979..2460554 + 576 WP_026001787.1 hypothetical protein -
CLM76_RS11575 2460576..2461100 - 525 WP_016914537.1 helix-turn-helix domain-containing protein -
CLM76_RS11580 2461388..2462866 + 1479 WP_096922577.1 glutamate--tRNA ligase -
CLM76_RS11595 2463573..2464454 - 882 WP_205738318.1 NAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2452837..2461100 8263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-78)

Antitoxin

Cro/C1-type helix-turn-helix domain

(65-119)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9525.02 Da        Isoelectric Point: 10.5610

>T85823 WP_039176369.1 NZ_CP023656:2458894-2459145 [Halomonas hydrothermalis]
MKTITYRKSALKVLQRMPRPESKRIQGKIKAYAEDPESQRNNVKALKGSDYIRLRVGDWRVIIDEHGDVLDIINIGARGG
VYQ

Download         Length: 252 bp

>T85823 NZ_CP023656:2458894-2459145 [Halomonas hydrothermalis]
ATGAAAACGATAACTTACCGTAAAAGCGCGTTGAAGGTGTTGCAGCGAATGCCGCGACCTGAGTCGAAGCGCATACAAGG
CAAAATCAAGGCCTATGCGGAAGACCCGGAAAGCCAGCGCAACAATGTGAAGGCCTTGAAGGGGAGCGATTATATTCGGC
TGCGGGTAGGCGACTGGCGGGTGATCATCGACGAGCATGGCGATGTACTCGACATCATTAACATCGGTGCCCGTGGCGGC
GTTTATCAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 12884.59 Da        Isoelectric Point: 4.1383

>AT85823 WP_039176367.1 NZ_CP023656:2459184-2459546 [Halomonas hydrothermalis]
MSIPQIIQTPTGERLVVLPEQEYQALLARLEDQDDIDAANAVVARGEESFPVAVVDALLDGVAPVKVYREYRGLRAGELA
EKAGISQGYLSEIESGKKSGSLSVLTRIATALEVELSDLT

Download         Length: 363 bp

>AT85823 NZ_CP023656:2459184-2459546 [Halomonas hydrothermalis]
ATGAGCATACCTCAAATTATTCAAACGCCCACGGGCGAGCGGTTAGTGGTTCTGCCTGAGCAGGAGTACCAGGCGTTGCT
TGCGCGGCTGGAAGACCAGGACGATATTGACGCTGCCAACGCGGTGGTGGCGCGTGGTGAAGAGTCATTTCCTGTGGCGG
TTGTGGATGCGCTGCTGGATGGCGTGGCACCCGTGAAGGTGTACCGCGAATACCGTGGACTACGTGCAGGTGAGCTGGCG
GAAAAAGCAGGGATCAGCCAAGGGTACCTTTCCGAAATAGAGTCAGGGAAAAAAAGCGGCTCGTTGAGTGTGCTGACCCG
TATTGCGACTGCTTTAGAGGTTGAACTGAGCGACCTTACCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References