Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2317523..2318025 Replicon chromosome
Accession NZ_CP023656
Organism Halomonas hydrothermalis strain Y2

Toxin (Protein)


Gene name relE Uniprot ID A0A857GIF8
Locus tag CLM76_RS10890 Protein ID WP_016914643.1
Coordinates 2317523..2317777 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6H1Y4Z8
Locus tag CLM76_RS10895 Protein ID WP_039176654.1
Coordinates 2317774..2318025 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM76_RS10865 2312590..2312895 + 306 WP_096922482.1 hypothetical protein -
CLM76_RS10870 2312904..2313608 + 705 WP_157779968.1 hypothetical protein -
CLM76_RS10875 2313708..2314379 + 672 WP_096922484.1 hypothetical protein -
CLM76_RS10880 2314500..2316377 + 1878 WP_096922485.1 AAA family ATPase -
CLM76_RS10885 2316449..2317108 + 660 WP_157779969.1 hypothetical protein -
CLM76_RS10890 2317523..2317777 - 255 WP_016914643.1 Txe/YoeB family addiction module toxin Toxin
CLM76_RS10895 2317774..2318025 - 252 WP_039176654.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CLM76_RS10900 2318189..2319010 - 822 WP_096922487.1 aldo/keto reductase -
CLM76_RS10905 2319421..2320350 - 930 WP_052196346.1 LysR family transcriptional regulator -
CLM76_RS10910 2320506..2321711 + 1206 WP_096922488.1 MFS transporter -
CLM76_RS10915 2321745..2322626 - 882 WP_096922489.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2310385..2323700 13315


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10234.85 Da        Isoelectric Point: 9.8162

>T85822 WP_016914643.1 NZ_CP023656:c2317777-2317523 [Halomonas hydrothermalis]
MKLIFSENAWEDYLYWQKTDKKILNRINKLIKEIKREPFEGVGKPEPLKHSLAGYWSRRINEEHRIVYKVTDDALLVAQL
RYHY

Download         Length: 255 bp

>T85822 NZ_CP023656:c2317777-2317523 [Halomonas hydrothermalis]
ATGAAGCTCATCTTTTCCGAGAACGCCTGGGAAGACTATTTGTACTGGCAGAAAACTGACAAAAAGATTCTCAACCGAAT
CAACAAGCTAATCAAAGAAATCAAGCGAGAGCCATTTGAAGGAGTCGGCAAGCCAGAACCCCTTAAACACAGCCTCGCGG
GTTACTGGTCTCGGCGAATCAACGAAGAACACCGCATCGTTTACAAGGTCACGGATGACGCTTTGCTTGTTGCCCAACTG
CGGTATCACTACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9280.52 Da        Isoelectric Point: 4.4750

>AT85822 WP_039176654.1 NZ_CP023656:c2318025-2317774 [Halomonas hydrothermalis]
MDAISYTAARTNLAKTMEQVCEDHSPVIITRNKAQSVVMISLEDYEALQETAYLLRAPKNARRLLESVAELEQGGGQEKE
LLE

Download         Length: 252 bp

>AT85822 NZ_CP023656:c2318025-2317774 [Halomonas hydrothermalis]
ATGGATGCCATCAGCTACACCGCCGCTAGAACCAACCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCCCCTGT
GATCATCACCCGCAACAAGGCGCAATCCGTGGTCATGATCTCTCTCGAAGACTATGAAGCACTGCAAGAGACAGCCTACC
TCCTGCGCGCGCCCAAAAACGCCCGCCGTTTACTGGAATCCGTTGCCGAGTTGGAGCAAGGGGGCGGTCAGGAAAAGGAG
CTTCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857GIF8

Antitoxin

Source ID Structure
AlphaFold DB A0A6H1Y4Z8

References