Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2976449..2977097 Replicon chromosome
Accession NZ_CP023614
Organism Mycobacterium tuberculosis strain LN3588

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag CP470_RS14545 Protein ID WP_052635321.1
Coordinates 2976449..2976772 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag CP470_RS14550 Protein ID WP_003899415.1
Coordinates 2976852..2977097 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CP470_RS14525 2972023..2973284 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
CP470_RS14530 2973658..2975097 - 1440 WP_003899411.1 phage major capsid protein -
CP470_RS14535 2975105..2975638 - 534 WP_003899412.1 HK97 family phage prohead protease -
CP470_RS14540 2975791..2976282 - 492 WP_003900541.1 phage terminase small subunit P27 family -
CP470_RS14545 2976449..2976772 - 324 WP_052635321.1 type II toxin-antitoxin system toxin Toxin
CP470_RS14550 2976852..2977097 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
CP470_RS14555 2977094..2978521 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
CP470_RS14560 2978523..2978915 - 393 WP_003899417.1 DUF2742 domain-containing protein -
CP470_RS14565 2978912..2979172 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
CP470_RS14570 2979189..2979551 - 363 WP_003900543.1 hypothetical protein -
CP470_RS14575 2979554..2980681 - 1128 WP_003899420.1 site-specific integrase -
CP470_RS14580 2980826..2981053 - 228 WP_003899421.1 hypothetical protein -
CP470_RS14585 2981050..2981439 - 390 WP_003899422.1 hypothetical protein -
CP470_RS14590 2981345..2981617 + 273 WP_003900544.1 hypothetical protein -
CP470_RS14595 2981716..2981949 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970414..2980681 10267


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12328.80 Da        Isoelectric Point: 8.6717

>T84203 WP_052635321.1 NZ_CP023614:c2976772-2976449 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRPHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T84203 NZ_CP023614:c2976772-2976449 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCC
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT84203 WP_003899415.1 NZ_CP023614:c2977097-2976852 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT84203 NZ_CP023614:c2977097-2976852 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References