Detailed information of TA system TA084203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/-
• Location: 2976449..2977097
• Replicon: chromosome
• Accession: NZ_CP023614
• Organism: Mycobacterium tuberculosis strain LN3588

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: CP470_RS14545
• Protein ID: WP_052635321.1
• Coordinates: 2976449..2976772 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ10
• Locus tag: CP470_RS14550
• Protein ID: WP_003899415.1
• Coordinates: 2976852..2977097 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CP470_RS14525	2972023..2973284	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
CP470_RS14530	2973658..2975097	-	1440	WP_003899411.1	phage major capsid protein	-
CP470_RS14535	2975105..2975638	-	534	WP_003899412.1	HK97 family phage prohead protease	-
CP470_RS14540	2975791..2976282	-	492	WP_003900541.1	phage terminase small subunit P27 family	-
CP470_RS14545	2976449..2976772	-	324	WP_052635321.1	type II toxin-antitoxin system toxin	Toxin
CP470_RS14550	2976852..2977097	-	246	WP_003899415.1	type II toxin-antitoxin system antitoxin	Antitoxin
CP470_RS14555	2977094..2978521	-	1428	WP_003899416.1	DUF3631 domain-containing protein	-
CP470_RS14560	2978523..2978915	-	393	WP_003899417.1	DUF2742 domain-containing protein	-
CP470_RS14565	2978912..2979172	-	261	WP_003899418.1	helix-turn-helix domain-containing protein	-
CP470_RS14570	2979189..2979551	-	363	WP_003900543.1	hypothetical protein	-
CP470_RS14575	2979554..2980681	-	1128	WP_003899420.1	site-specific integrase	-
CP470_RS14580	2980826..2981053	-	228	WP_003899421.1	hypothetical protein	-
CP470_RS14585	2981050..2981439	-	390	WP_003899422.1	hypothetical protein	-
CP470_RS14590	2981345..2981617	+	273	WP_003900544.1	hypothetical protein	-
CP470_RS14595	2981716..2981949	+	234	WP_003413717.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_000962 Mycobacterium tuberculosis H37Rv Prophage TA000120 2970551..2980818 0	inside	Prophage	-	-	2970414..2980681	10267

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12328.80 Da
• Isoelectric Point: 8.6717

>T84203 WP_052635321.1 NZ_CP023614:c2976772-2976449 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRPHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Nucleotide

• Length: 324 bp

>T84203 NZ_CP023614:c2976772-2976449 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCC
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 7697.71 Da
• Isoelectric Point: 4.8565

>AT84203 WP_003899415.1 NZ_CP023614:c2977097-2976852 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Nucleotide

• Length: 246 bp

>AT84203 NZ_CP023614:c2977097-2976852 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A806JR81