Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1643329..1643984 Replicon chromosome
Accession NZ_CP023563
Organism Brachybacterium vulturis strain VM2412

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CFK38_RS07400 Protein ID WP_096804262.1
Coordinates 1643559..1643984 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CFK38_RS07395 Protein ID WP_096802497.1
Coordinates 1643329..1643562 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFK38_RS07345 1639143..1639424 + 282 WP_096802489.1 type II toxin-antitoxin system RelE/ParE family toxin -
CFK38_RS07350 1639399..1639719 + 321 WP_096802490.1 HigA family addiction module antidote protein -
CFK38_RS07355 1639716..1640540 + 825 WP_096802491.1 alpha/beta hydrolase -
CFK38_RS07365 1641117..1641359 + 243 WP_096802492.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CFK38_RS07370 1641356..1641613 + 258 WP_096802493.1 type II toxin-antitoxin system RelE/ParE family toxin -
CFK38_RS07375 1641848..1642108 + 261 WP_096802494.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CFK38_RS07380 1642109..1642363 + 255 WP_096802495.1 Txe/YoeB family addiction module toxin -
CFK38_RS07385 1642597..1642926 + 330 WP_096802496.1 nucleotidyltransferase domain-containing protein -
CFK38_RS07390 1642923..1643168 + 246 Protein_1453 DUF86 domain-containing protein -
CFK38_RS07395 1643329..1643562 + 234 WP_096802497.1 Arc family DNA-binding protein Antitoxin
CFK38_RS07400 1643559..1643984 + 426 WP_096804262.1 type II toxin-antitoxin system VapC family toxin Toxin
CFK38_RS07405 1644132..1644707 - 576 WP_096802498.1 hypothetical protein -
CFK38_RS07410 1644817..1645614 - 798 WP_157773402.1 hypothetical protein -
CFK38_RS07415 1645625..1645978 - 354 WP_096802500.1 PadR family transcriptional regulator -
CFK38_RS07420 1646093..1646701 + 609 WP_096802501.1 TetR/AcrR family transcriptional regulator -
CFK38_RS07425 1646698..1648107 + 1410 WP_096802502.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(11-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15128.17 Da        Isoelectric Point: 4.9305

>T81630 WP_096804262.1 NZ_CP023563:1643559-1643984 [Brachybacterium vulturis]
VIVLDTNVISEIFRPSPEVRVVDWLASLTGDVAITSVTLAELLAGVRRLPDGRRKDELTRRIEVALEPYRGSRSVLPFDG
SAAERYTDVLVARESAGAPISTADAQIAAICLTHGATCATRNVKDFAHTGIELVDPWSATG

Download         Length: 426 bp

>T81630 NZ_CP023563:1643559-1643984 [Brachybacterium vulturis]
GTGATCGTCCTCGACACGAACGTCATCTCGGAGATCTTCCGGCCGTCGCCGGAGGTGCGCGTGGTCGATTGGCTCGCGTC
GTTGACGGGTGATGTCGCGATCACGTCCGTCACGCTCGCGGAGCTGCTGGCTGGTGTGCGGCGACTCCCGGACGGTCGGC
GCAAGGATGAGTTGACCAGGCGCATCGAGGTGGCGCTCGAGCCGTATCGGGGGAGTCGCTCGGTGCTTCCGTTCGATGGC
TCGGCGGCCGAACGTTATACCGACGTCCTCGTTGCTCGGGAGAGTGCGGGAGCACCGATCAGCACGGCCGACGCGCAGAT
CGCCGCGATCTGCCTGACGCACGGAGCGACCTGCGCGACGCGCAACGTCAAGGATTTCGCGCATACCGGCATCGAGCTGG
TCGACCCGTGGAGCGCCACCGGGTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8411.58 Da        Isoelectric Point: 6.4684

>AT81630 WP_096802497.1 NZ_CP023563:1643329-1643562 [Brachybacterium vulturis]
MSSIIVRGLDEAVKKRLAAQAKEHGRSMEAEVREILTQASRRPHIGMALLSAAQDAGGVEDLPIARRDDVARSVEFE

Download         Length: 234 bp

>AT81630 NZ_CP023563:1643329-1643562 [Brachybacterium vulturis]
ATGTCATCCATCATCGTTCGCGGGCTCGACGAAGCAGTGAAGAAGCGGCTCGCCGCGCAGGCGAAGGAGCACGGCCGTTC
CATGGAGGCCGAGGTCCGCGAGATCCTGACCCAGGCCTCGCGACGGCCGCACATCGGAATGGCGCTGCTGTCCGCGGCGC
AGGATGCCGGCGGAGTCGAGGACCTGCCGATCGCGAGGCGCGACGACGTCGCACGGTCCGTGGAGTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References