Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 2717567..2718289 Replicon chromosome
Accession NZ_CP023529
Organism Lelliottia amnigena strain FDAARGOS_395

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3S5XTH1
Locus tag CO697_RS13295 Protein ID WP_059177462.1
Coordinates 2717567..2717887 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A3S5XU25
Locus tag CO697_RS13300 Protein ID WP_059177461.1
Coordinates 2717954..2718289 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO697_RS13275 2713796..2715691 + 1896 WP_072241722.1 RNA polymerase sigma factor RpoD -
CO697_RS13280 2715810..2716316 - 507 WP_059177464.1 G/U mismatch-specific DNA glycosylase -
CO697_RS13290 2716620..2717453 - 834 WP_059177463.1 DUF4942 domain-containing protein -
CO697_RS13295 2717567..2717887 - 321 WP_059177462.1 TA system toxin CbtA family protein Toxin
CO697_RS13300 2717954..2718289 - 336 WP_059177461.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CO697_RS13305 2718304..2718783 - 480 WP_059177460.1 DNA repair protein RadC -
CO697_RS13310 2719143..2719292 - 150 WP_082691897.1 transposase -
CO697_RS13315 2719441..2720568 + 1128 WP_059177459.1 hypothetical protein -
CO697_RS13320 2720573..2721121 + 549 WP_059177458.1 MarR family transcriptional regulator -
CO697_RS13325 2721258..2722349 + 1092 WP_059177457.1 multiubiquitin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(13-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12075.72 Da        Isoelectric Point: 5.5094

>T81513 WP_059177462.1 NZ_CP023529:c2717887-2717567 [Lelliottia amnigena]
MQTSTVPVTVPVLSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T81513 NZ_CP023529:c2717887-2717567 [Lelliottia amnigena]
ATGCAAACCTCAACTGTACCGGTCACGGTGCCGGTTTTGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAACTGTTAAC
GTACCTGTTAGAACACCATTACGGTCTGACACTTAACGACACGCCATTCCATGATGACGCGGCCATCCAGGAGCATATCG
AAGCGGGAATAACATTGGCTGATGCGGTGAATTTCCTGGTGGAACGTTATGAGCTGGTGCGCACCGACCGCAAAGGATTT
ACCTGGCAGGAGCAGACGCCATTCCTGACCGCTACCGATATTCTCAGAGCAAGGCGAGCTACCGGATTAATAAACACGTA
A

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12616.49 Da        Isoelectric Point: 6.4763

>AT81513 WP_059177461.1 NZ_CP023529:c2718289-2717954 [Lelliottia amnigena]
MNKDVTQTWGLKREITPCFGARLVQEGHRLHFLADWAGFTGMFSEVQALQLDEAFPHFVAHLELMLLSCELNPRYAHCVT
LYRNGLTCEADTLGSHGFVYIAIYPSKQVKD

Download         Length: 336 bp

>AT81513 NZ_CP023529:c2718289-2717954 [Lelliottia amnigena]
ATGAATAAAGACGTTACACAAACCTGGGGTCTTAAACGAGAGATCACACCGTGTTTTGGAGCACGGCTGGTGCAGGAAGG
CCATCGTCTGCATTTTCTGGCGGACTGGGCAGGATTCACCGGTATGTTCAGTGAGGTACAGGCCCTACAACTGGATGAAG
CCTTCCCTCATTTTGTCGCACATCTGGAGCTGATGCTGCTCTCCTGTGAACTGAATCCCCGGTACGCGCACTGCGTCACG
CTGTACCGTAACGGGTTGACCTGTGAAGCCGATACGCTGGGTAGTCATGGGTTTGTATATATCGCAATTTATCCCTCAAA
ACAGGTTAAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XTH1

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XU25

References