Detailed information of TA system TA081511

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2311334..2312053
• Replicon: chromosome
• Accession: NZ_CP023529
• Organism: Lelliottia amnigena strain FDAARGOS_395

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A2A7T6H5
• Locus tag: CO697_RS11340
• Protein ID: WP_004390416.1
• Coordinates: 2311733..2312053 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2A7T740
• Locus tag: CO697_RS11335
• Protein ID: WP_032819787.1
• Coordinates: 2311334..2311699 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CO697_RS11295	2306467..2307090	-	624	WP_032819788.1	inovirus Gp2 family protein	-
CO697_RS11300	2307684..2308118	+	435	WP_004390423.1	hypothetical protein	-
CO697_RS11305	2308138..2308941	+	804	WP_004390422.1	hypothetical protein	-
CO697_RS11310	2308992..2309171	+	180	WP_004390421.1	hypothetical protein	-
CO697_RS11320	2309711..2310532	+	822	WP_004390419.1	DUF945 domain-containing protein	-
CO697_RS11325	2310602..2311072	+	471	WP_059177775.1	DNA repair protein RadC	-
CO697_RS11330	2311081..2311302	+	222	WP_059177774.1	DUF987 domain-containing protein	-
CO697_RS11335	2311334..2311699	+	366	WP_032819787.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CO697_RS11340	2311733..2312053	+	321	WP_004390416.1	TA system toxin CbtA family protein	Toxin
CO697_RS11345	2312673..2313527	+	855	WP_059177773.1	kinase	-
CO697_RS21990	2313682..2313837	+	156	WP_164841588.1	hypothetical protein	-
CO697_RS11350	2313967..2314323	+	357	WP_059177772.1	hypothetical protein	-
CO697_RS11355	2314443..2314994	+	552	WP_059177771.1	YceI family protein	-
CO697_RS11360	2314989..2315777	-	789	WP_059177770.1	hypothetical protein	-
CO697_RS11365	2315774..2316289	-	516	WP_174521002.1	sigma-70 family RNA polymerase sigma factor	-
CO697_RS11370	2316310..2316855	-	546	WP_059177768.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-105)

Antitoxin

• Antitoxin CbeA (18-116)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12131.83 Da
• Isoelectric Point: 6.2084

>T81511 WP_004390416.1 NZ_CP023529:2311733-2312053 [Lelliottia amnigena]
MHISTVPATVPVSPRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTTIDLLRARRATGLVHT

Nucleotide

• Length: 321 bp

>T81511 NZ_CP023529:2311733-2312053 [Lelliottia amnigena]
ATGCATATTTCAACTGTACCGGCCACGGTGCCGGTTTCGCCACGCCTGTCGCCCGTTCAGGTCTGGCAGCAACTGTTAAC
GTACCTACTGGAACACCATTACGGTCTTACGCTCAACGACACACCATTCCATGATGATTCAGCCATCCAGGAACATATCG
AGGCGGGTATCACACTTGCTGATGCGGTGAATTTCCTGGTGGAACGCTATGAACTGGTGCGCATCGACCGTAAAGGATTC
ACCTGGCAAGAGCAGACACCATTCCTGACTACTATCGATTTACTCAGAGCCAGGCGAGCTACCGGATTAGTGCACACATA
A

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13476.24 Da
• Isoelectric Point: 6.0589

>AT81511 WP_032819787.1 NZ_CP023529:2311334-2311699 [Lelliottia amnigena]
MQSTTLSGSSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLTDRAGFDGSFSDDEALRLDQVFPLMMKQLERMLTTGE
LDPRCQHCVTLHHNGLTCEADTLGSHGYVYIAIYPQSAVTR

Nucleotide

• Length: 366 bp

>AT81511 NZ_CP023529:2311334-2311699 [Lelliottia amnigena]
ATGCAATCGACCACCTTATCCGGCTCATCAGCGGAGAACGCATCCTGCCTTCAGTGGGGATTAAAACGTAATATCACGCC
GTGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGTCTCTACTTTCTGACTGATCGGGCTGGGTTTGATGGCTCATTCA
GTGACGATGAAGCATTGCGTCTGGACCAGGTGTTTCCACTGATGATGAAACAGCTAGAGCGGATGCTCACCACTGGAGAG
CTTGATCCCCGCTGTCAACACTGCGTCACTCTGCATCACAATGGACTCACCTGTGAAGCTGACACTCTCGGCTCTCATGG
TTACGTTTACATCGCTATTTATCCCCAGTCAGCCGTAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A2A7T6H5

Antitoxin

• AlphaFold DB: A0A2A7T740