Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 59488..60131 Replicon plasmid pSalSendai
Accession NZ_CP023471
Organism Salmonella enterica subsp. enterica strain BAA-1672

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag CO195_RS23370 Protein ID WP_001044768.1
Coordinates 59715..60131 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag CO195_RS23365 Protein ID WP_001261287.1
Coordinates 59488..59718 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO195_RS23315 54738..54986 + 249 Protein_66 hypothetical protein -
CO195_RS23320 55011..55301 + 291 WP_048889372.1 hypothetical protein -
CO195_RS23330 55943..56920 + 978 WP_048889370.1 RepB family plasmid replication initiator protein -
CO195_RS23335 57181..57381 - 201 Protein_69 hypothetical protein -
CO195_RS23340 57572..58378 - 807 WP_117335825.1 site-specific integrase -
CO195_RS23345 58379..58684 - 306 WP_001159866.1 type II toxin-antitoxin system toxin CcdB -
CO195_RS23350 58686..58904 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
CO195_RS23365 59488..59718 + 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CO195_RS23370 59715..60131 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
CO195_RS23380 60522..60845 + 324 Protein_75 hypothetical protein -
CO195_RS23650 61147..61485 - 339 WP_162887451.1 hypothetical protein -
CO195_RS23395 61995..62213 - 219 WP_048889380.1 hypothetical protein -
CO195_RS23400 62319..62594 - 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin -
CO195_RS23405 62594..62878 - 285 WP_115376289.1 ribbon-helix-helix protein, CopG family -
CO195_RS23415 64148..64417 - 270 WP_048889368.1 hypothetical protein -
CO195_RS23750 64517..64755 + 239 Protein_81 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81125 81125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 17834.22 Da        Isoelectric Point: 12.9398

>T81311 WP_001044768.1 NZ_CP023471:59715-60131 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 417 bp

>T81311 NZ_CP023471:59715-60131 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT81311 WP_001261287.1 NZ_CP023471:59488-59718 [Salmonella enterica subsp. enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT81311 NZ_CP023471:59488-59718 [Salmonella enterica subsp. enterica]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References