Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1636365..1637118 Replicon chromosome
Accession NZ_CP023467
Organism Dickeya dadantii strain DSM 18020

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag CO076_RS07515 Protein ID WP_038910718.1
Coordinates 1636365..1636622 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag CO076_RS07520 Protein ID WP_038910719.1
Coordinates 1636630..1637118 (+) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO076_RS07505 1633140..1635290 - 2151 WP_038910717.1 formate dehydrogenase subunit alpha -
CO076_RS07510 1635325..1635867 - 543 WP_013317225.1 4Fe-4S dicluster domain-containing protein -
CO076_RS07515 1636365..1636622 + 258 WP_038910718.1 DUF4160 domain-containing protein Toxin
CO076_RS07520 1636630..1637118 + 489 WP_038910719.1 addiction module antitoxin Antitoxin
CO076_RS07525 1637203..1637697 - 495 WP_038910720.1 hydrogenase maturation peptidase HycI -
CO076_RS07530 1637690..1638088 - 399 WP_013317230.1 formate hydrogenlyase maturation HycH family protein -
CO076_RS07535 1638085..1638876 - 792 WP_038910721.1 NADH-quinone oxidoreductase subunit B family protein -
CO076_RS07540 1638873..1639442 - 570 WP_038910722.1 hydrogenase 4 subunit H -
CO076_RS07545 1639453..1641180 - 1728 WP_038910724.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(80-157)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10102.70 Da        Isoelectric Point: 9.5721

>T81296 WP_038910718.1 NZ_CP023467:1636365-1636622 [Dickeya dadantii]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGNHELIINIRTGTEIEGYLPNNKRKLALAHIRAHRQQLLSMWERAVVRR
NPGKL

Download         Length: 258 bp

>T81296 NZ_CP023467:1636365-1636622 [Dickeya dadantii]
ATGCCTGAGATTGACAGACTGGCGGGGCTGATTTTCCATTTGTACTTTTACGACGATGAGCGGCATCACTTACCGCATGT
CCATGTCTGCTACGGCAACCATGAACTTATCATCAATATTCGTACCGGAACCGAGATCGAAGGATATCTGCCGAATAACA
AGCGCAAGCTGGCGCTTGCGCATATCAGGGCCCACCGGCAGCAACTGCTGAGTATGTGGGAACGGGCGGTAGTGAGGAGA
AATCCGGGAAAACTGTGA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 17997.57 Da        Isoelectric Point: 6.8732

>AT81296 WP_038910719.1 NZ_CP023467:1636630-1637118 [Dickeya dadantii]
MHKIVEVDVIGDFSLRLTYEDGLVCDINLYLYAPSPVFSNASQFIKFGLLPDGSLEWLPDIRISASELRKKGEYVSHTLA
VRERNFADVISRAFYDAVIENRPEILQAALKTAVEKHGNSTVAKEAGAKSRTSLYKSLNKNTNVSLATVVSLAHTVLQLE
EK

Download         Length: 489 bp

>AT81296 NZ_CP023467:1636630-1637118 [Dickeya dadantii]
ATGCATAAGATCGTGGAAGTTGACGTCATTGGCGATTTTTCGTTGCGCCTGACCTATGAAGATGGTCTGGTTTGCGACAT
CAATCTTTATCTCTATGCCCCCAGCCCGGTGTTTTCGAACGCCAGCCAGTTTATCAAATTTGGCCTGCTGCCGGACGGTT
CGCTGGAATGGCTGCCGGATATTAGGATTTCCGCGTCGGAATTGCGGAAAAAAGGGGAGTATGTCAGCCACACGCTCGCG
GTGCGAGAAAGGAACTTCGCTGATGTTATCTCTCGCGCCTTCTATGATGCCGTGATTGAAAACCGGCCGGAAATTCTGCA
AGCGGCGTTGAAAACCGCGGTGGAAAAACATGGCAACAGCACCGTAGCCAAAGAGGCGGGGGCGAAAAGCCGCACCAGCC
TGTATAAGTCGCTGAATAAGAATACCAATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCACACCGTGCTGCAACTGGAA
GAAAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References