Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4770883..4771399 Replicon chromosome
Accession NZ_CP023416
Organism Klebsiella pneumoniae strain 1050

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag CN260_RS24035 Protein ID WP_004178374.1
Coordinates 4770883..4771167 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag CN260_RS24040 Protein ID WP_002886901.1
Coordinates 4771157..4771399 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CN260_RS24015 4766273..4766581 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
CN260_RS31505 4766666..4766839 + 174 WP_032431440.1 hypothetical protein -
CN260_RS24020 4766842..4767585 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
CN260_RS24025 4767942..4770080 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
CN260_RS24030 4770415..4770879 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
CN260_RS24035 4770883..4771167 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CN260_RS24040 4771157..4771399 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CN260_RS24045 4771477..4773387 - 1911 WP_004152270.1 BglG family transcription antiterminator -
CN260_RS24050 4773410..4774564 - 1155 WP_023280781.1 lactonase family protein -
CN260_RS24055 4774631..4775371 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T81241 WP_004178374.1 NZ_CP023416:c4771167-4770883 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T81241 NZ_CP023416:c4771167-4770883 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT81241 WP_002886901.1 NZ_CP023416:c4771399-4771157 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT81241 NZ_CP023416:c4771399-4771157 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References