Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2742953..2743484 Replicon chromosome
Accession NZ_CP023415
Organism Desulfovibrio sp. G11

Toxin (Protein)


Gene name relE Uniprot ID A0A807ZMP4
Locus tag CNY67_RS12440 Protein ID WP_072311512.1
Coordinates 2743188..2743484 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7W8FFT7
Locus tag CNY67_RS12435 Protein ID WP_072311511.1
Coordinates 2742953..2743198 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNY67_RS15785 2738264..2739217 + 954 WP_143142576.1 hypothetical protein -
CNY67_RS12410 2739232..2740095 + 864 WP_096152720.1 restriction endonuclease -
CNY67_RS12415 2740207..2740479 + 273 WP_072311507.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CNY67_RS12420 2740460..2740720 + 261 WP_072311508.1 Txe/YoeB family addiction module toxin -
CNY67_RS12425 2740891..2741592 + 702 WP_072311509.1 ERF family protein -
CNY67_RS12430 2741661..2742824 + 1164 WP_072311510.1 hypothetical protein -
CNY67_RS12435 2742953..2743198 + 246 WP_072311511.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CNY67_RS12440 2743188..2743484 + 297 WP_072311512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNY67_RS12445 2743634..2744986 + 1353 WP_072311531.1 AAA family ATPase -
CNY67_RS12450 2744996..2746033 + 1038 WP_096152721.1 DUF3150 domain-containing protein -
CNY67_RS12455 2746038..2747666 + 1629 WP_072311513.1 VWA domain-containing protein -
CNY67_RS12460 2747923..2748090 + 168 WP_096152722.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2712808..2749295 36487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-64)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11615.64 Da        Isoelectric Point: 10.2579

>T81226 WP_072311512.1 NZ_CP023415:2743188-2743484 [Desulfovibrio sp. G11]
MSYSLQFHEIALKEWRKLDASIREQFKKKLAERLEHPRVPSSALSGMRDCYKIKLRSIGYRLVYMVDDGILFVTVISIGK
RERLEVYRKALQRVTPEE

Download         Length: 297 bp

>T81226 NZ_CP023415:2743188-2743484 [Desulfovibrio sp. G11]
ATGAGCTATAGTCTGCAGTTTCATGAGATTGCGCTGAAGGAGTGGAGAAAACTGGATGCCAGCATCCGGGAACAGTTTAA
AAAGAAACTGGCTGAACGTTTGGAACATCCACGGGTTCCTTCATCCGCTTTGTCTGGCATGCGCGATTGCTATAAAATAA
AACTGCGCTCAATTGGATATCGGCTGGTGTACATGGTGGATGATGGCATCCTCTTTGTTACAGTCATTTCCATTGGCAAG
CGTGAACGCCTTGAAGTATATCGGAAGGCTTTGCAACGTGTGACTCCAGAAGAATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9050.34 Da        Isoelectric Point: 4.8081

>AT81226 WP_072311511.1 NZ_CP023415:2742953-2743198 [Desulfovibrio sp. G11]
MDPIHANITVSVTELKRNFANILATAKDAPVAVLNHNKPEAYLLSAKHYEEILGILEDLEDKKIVESREHGPFVTVTLDE
L

Download         Length: 246 bp

>AT81226 NZ_CP023415:2742953-2743198 [Desulfovibrio sp. G11]
ATGGATCCTATACACGCCAATATTACAGTGAGTGTCACGGAACTCAAACGCAATTTTGCAAATATTTTGGCTACTGCCAA
GGATGCTCCGGTGGCAGTTTTGAACCACAACAAACCGGAAGCCTACCTTTTGTCCGCAAAGCATTACGAAGAAATCCTTG
GAATCCTTGAAGACCTTGAAGACAAGAAGATCGTCGAAAGCCGCGAGCATGGCCCTTTTGTCACGGTGACGCTTGATGAG
CTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807ZMP4

Antitoxin

Source ID Structure
AlphaFold DB A0A7W8FFT7

References