Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2560365..2560549 Replicon chromosome
Accession NZ_CP023390
Organism Staphylococcus aureus subsp. aureus str. Newman strain NYU_Newman

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CNH35_RS13700 Protein ID WP_000482650.1
Coordinates 2560442..2560549 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2560365..2560425 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNH35_RS13675 2555895..2556062 - 168 WP_001790576.1 hypothetical protein -
CNH35_RS13685 2556293..2558026 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CNH35_RS13690 2558051..2559814 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2560365..2560425 + 61 - - Antitoxin
CNH35_RS13700 2560442..2560549 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
CNH35_RS13705 2560683..2561069 - 387 WP_000779358.1 flippase GtxA -
CNH35_RS13710 2561337..2562479 + 1143 WP_001176863.1 glycerate kinase -
CNH35_RS13715 2562539..2563198 + 660 WP_000831298.1 membrane protein -
CNH35_RS13720 2563380..2564591 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
CNH35_RS13725 2564714..2565187 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T81180 WP_000482650.1 NZ_CP023390:c2560549-2560442 [Staphylococcus aureus subsp. aureus str. Newman]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T81180 NZ_CP023390:c2560549-2560442 [Staphylococcus aureus subsp. aureus str. Newman]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT81180 NZ_CP023390:2560365-2560425 [Staphylococcus aureus subsp. aureus str. Newman]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References