Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3403135..3403967 Replicon chromosome
Accession NZ_CP023349
Organism Escherichia coli strain ETEC-2264

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag CJU63_RS17745 Protein ID WP_000854753.1
Coordinates 3403593..3403967 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag CJU63_RS17740 Protein ID WP_001278232.1
Coordinates 3403135..3403503 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJU63_RS17705 3399954..3400409 + 456 WP_000581504.1 hypothetical protein -
CJU63_RS17710 3400488..3400721 + 234 WP_001119729.1 DUF905 family protein -
CJU63_RS17720 3400821..3401639 + 819 WP_001234631.1 DUF945 domain-containing protein -
CJU63_RS17725 3401721..3402200 + 480 WP_000860064.1 antirestriction protein -
CJU63_RS17730 3402212..3402688 + 477 WP_001186710.1 RadC family protein -
CJU63_RS17735 3402751..3402972 + 222 WP_000692303.1 DUF987 domain-containing protein -
CJU63_RS17740 3403135..3403503 + 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CJU63_RS17745 3403593..3403967 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
CJU63_RS17750 3403964..3404452 + 489 WP_000777541.1 hypothetical protein -
CJU63_RS17755 3404464..3404661 + 198 WP_000839281.1 DUF957 domain-containing protein -
CJU63_RS17760 3404758..3405327 + 570 WP_001290243.1 DUF4942 domain-containing protein -
CJU63_RS17765 3405608..3406144 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
CJU63_RS17770 3406146..3407324 - 1179 WP_000094974.1 type II secretion system protein GspL -
CJU63_RS17775 3407321..3408298 - 978 WP_000633220.1 type II secretion system minor pseudopilin GspK -
CJU63_RS17780 3408301..3408900 - 600 WP_001255040.1 type II secretion system minor pseudopilin GspJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T80812 WP_000854753.1 NZ_CP023349:3403593-3403967 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T80812 NZ_CP023349:3403593-3403967 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT80812 WP_001278232.1 NZ_CP023349:3403135-3403503 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT80812 NZ_CP023349:3403135-3403503 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References