Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 529157..529923 Replicon chromosome
Accession NZ_CP023209
Organism Vibrio anguillarum strain ATCC-68554

Toxin (Protein)


Gene name - Uniprot ID F7YRS3
Locus tag CLI14_RS16775 Protein ID WP_013867769.1
Coordinates 529157..529654 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID F7YRS4
Locus tag CLI14_RS16780 Protein ID WP_013867770.1
Coordinates 529651..529923 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLI14_RS16730 525626..525979 - 354 WP_011154649.1 IS66 family insertion sequence element accessory protein TnpB -
CLI14_RS16735 525976..526293 - 318 WP_011154648.1 IS66 family insertion sequence hypothetical protein -
CLI14_RS16740 526408..526500 + 93 WP_019281220.1 DUF3265 domain-containing protein -
CLI14_RS16745 526588..526794 + 207 WP_013867765.1 DUF1289 domain-containing protein -
CLI14_RS16750 526914..527144 - 231 WP_013867766.1 PAS factor family protein -
CLI14_RS16755 527438..527674 - 237 WP_013867767.1 hypothetical protein -
CLI14_RS16760 527959..528447 + 489 WP_013867768.1 hypothetical protein -
CLI14_RS16765 528438..528569 + 132 Protein_465 DUF3265 domain-containing protein -
CLI14_RS16775 529157..529654 - 498 WP_013867769.1 GNAT family N-acetyltransferase Toxin
CLI14_RS16780 529651..529923 - 273 WP_013867770.1 DUF1778 domain-containing protein Antitoxin
CLI14_RS16790 530674..531393 + 720 Protein_468 hypothetical protein -
CLI14_RS16795 531450..532370 - 921 WP_011154643.1 IS5-like element ISVa2 family transposase -
CLI14_RS16800 532475..532762 + 288 WP_157731538.1 potassium channel family protein -
CLI14_RS16805 533035..533424 + 390 WP_019280976.1 DUF1090 domain-containing protein -
CLI14_RS16810 533428..533517 + 90 WP_019280977.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 505576..533424 27848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18525.25 Da        Isoelectric Point: 9.2555

>T80636 WP_013867769.1 NZ_CP023209:c529654-529157 [Vibrio anguillarum]
MMNTVLLDKVKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNNSSHIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKYFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T80636 NZ_CP023209:c529654-529157 [Vibrio anguillarum]
ATGATGAATACGGTACTTTTAGATAAAGTTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAACACCAGAACGTTTGTTCTGGAAGATGATAACAACAGCTCAC
ATATCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAATTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGCCTAATTGCCCGTCTTGCTGTCGATGACAGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
CATCGATGCACTCAGAAAGCTATTAGCTGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CAAAATATTTTTATGAACGCTATGGCTTTCAGGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCGGATGTA
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9731.18 Da        Isoelectric Point: 8.6154

>AT80636 WP_013867770.1 NZ_CP023209:c529923-529651 [Vibrio anguillarum]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAILLMDALDRPTAQNSKLRA
ASERYESKAQ

Download         Length: 273 bp

>AT80636 NZ_CP023209:c529923-529651 [Vibrio anguillarum]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTCACTAAAGCTGCCGCTATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGCGCTGCAATTGAAAAGGCTAAACAAGTCATCGAACGTGAGCAAGCTT
TAAAACTGAGCCAAGCCGATGCGATTTTGCTGATGGACGCATTAGACCGCCCAACAGCACAGAACTCAAAACTAAGAGCG
GCCTCTGAACGATACGAGAGCAAGGCTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QZT4

Antitoxin

Source ID Structure
AlphaFold DB A0A7X8U164

References