Detailed information of TA system TA080353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 774160..774839
• Replicon: chromosome
• Accession: NZ_CP023034
• Organism: Acinetobacter baumannii strain 5845

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: Aba5845_RS03605
• Protein ID: WP_000838146.1
• Coordinates: 774160..774342 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: Aba5845_RS03610
• Protein ID: WP_000966688.1
• Coordinates: 774435..774839 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Aba5845_RS03560	769233..769637	+	405	WP_000247948.1	hypothetical protein	-
Aba5845_RS03565	769609..769977	+	369	WP_002055488.1	hypothetical protein	-
Aba5845_RS03570	769979..770377	+	399	WP_001251850.1	hypothetical protein	-
Aba5845_RS03575	770379..770597	+	219	WP_001277687.1	hypothetical protein	-
Aba5845_RS03580	770691..771044	+	354	WP_000064599.1	hypothetical protein	-
Aba5845_RS03585	771044..772279	+	1236	WP_000002422.1	hypothetical protein	-
Aba5845_RS03590	772332..773249	+	918	WP_000094250.1	hypothetical protein	-
Aba5845_RS03595	773319..773834	+	516	WP_001185608.1	hypothetical protein	-
Aba5845_RS03605	774160..774342	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
Aba5845_RS03610	774435..774839	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Aba5845_RS03615	774938..775114	+	177	WP_014466185.1	hypothetical protein	-
Aba5845_RS03620	775123..775446	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
Aba5845_RS03625	775478..776272	+	795	WP_000720608.1	hypothetical protein	-
Aba5845_RS03630	776321..776560	-	240	WP_000763623.1	Arc family DNA-binding protein	-
Aba5845_RS03635	776683..776838	+	156	WP_001103649.1	Arc family DNA-binding protein	-
Aba5845_RS03640	776835..777827	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	741696..799987	58291

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T80353 WP_000838146.1 NZ_CP023034:774160-774342 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T80353 NZ_CP023034:774160-774342 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT80353 WP_000966688.1 NZ_CP023034:774435-774839 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT80353 NZ_CP023034:774435-774839 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6