Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3760137..3760924 Replicon chromosome
Accession NZ_CP022959
Organism Escherichia coli ATCC 8739

Toxin (Protein)


Gene name yeeV Uniprot ID A0A377E3D6
Locus tag CJZ69_RS18780 Protein ID WP_001194695.1
Coordinates 3760547..3760924 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2H9G3E7
Locus tag CJZ69_RS18775 Protein ID WP_000066236.1
Coordinates 3760137..3760496 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ69_RS18725 3755377..3755829 + 453 WP_001020418.1 hypothetical protein -
CJZ69_RS18730 3755826..3756278 + 453 WP_000734138.1 hypothetical protein -
CJZ69_RS18735 3756341..3756883 + 543 WP_001104018.1 DUF4339 domain-containing protein -
CJZ69_RS18740 3756942..3757394 + 453 WP_001061894.1 hypothetical protein -
CJZ69_RS18745 3757471..3757704 + 234 WP_001114682.1 DUF905 domain-containing protein -
CJZ69_RS18750 3757824..3758642 + 819 WP_001234406.1 DUF945 domain-containing protein -
CJZ69_RS18760 3758910..3759380 + 471 WP_000131762.1 antirestriction protein -
CJZ69_RS18765 3759392..3759871 + 480 WP_000437750.1 DNA repair protein RadC -
CJZ69_RS18770 3759892..3760113 + 222 WP_000691981.1 DUF987 domain-containing protein -
CJZ69_RS18775 3760137..3760496 + 360 WP_000066236.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CJZ69_RS18780 3760547..3760924 + 378 WP_001194695.1 TA system toxin CbtA family protein Toxin
CJZ69_RS18785 3760921..3761412 + 492 WP_000777682.1 hypothetical protein -
CJZ69_RS18790 3761444..3761647 + 204 WP_000413747.1 DUF957 domain-containing protein -
CJZ69_RS18795 3761728..3762572 + 845 Protein_3553 DUF4942 domain-containing protein -
CJZ69_RS18805 3762914..3763645 - 732 WP_001300756.1 DNA polymerase III subunit epsilon -
CJZ69_RS18810 3763710..3764177 + 468 WP_000917883.1 ribonuclease HI -
CJZ69_RS18815 3764174..3764896 - 723 WP_001297210.1 class I SAM-dependent methyltransferase -
CJZ69_RS18820 3764930..3765685 + 756 WP_001052717.1 hydroxyacylglutathione hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14180.97 Da        Isoelectric Point: 7.4209

>T80270 WP_001194695.1 NZ_CP022959:3760547-3760924 [Escherichia coli ATCC 8739]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR

Download         Length: 378 bp

>T80270 NZ_CP022959:3760547-3760924 [Escherichia coli ATCC 8739]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13127.02 Da        Isoelectric Point: 7.0261

>AT80270 WP_000066236.1 NZ_CP022959:3760137-3760496 [Escherichia coli ATCC 8739]
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA

Download         Length: 360 bp

>AT80270 NZ_CP022959:3760137-3760496 [Escherichia coli ATCC 8739]
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGTCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377E3D6

Antitoxin

Source ID Structure
AlphaFold DB A0A2H9G3E7

References