Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1517653..1519273 Replicon chromosome
Accession NZ_CP022958
Organism Azoarcus sp. DD4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CJ010_RS07210 Protein ID WP_205754969.1
Coordinates 1517653..1519008 (-) Length 452 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CJ010_RS07215 Protein ID WP_141017409.1
Coordinates 1519013..1519273 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJ010_RS07185 1513426..1513953 - 528 WP_141017404.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
CJ010_RS07190 1513972..1515165 - 1194 WP_141017405.1 urate hydroxylase PuuD -
CJ010_RS07195 1515202..1515552 - 351 WP_141017406.1 hydroxyisourate hydrolase -
CJ010_RS07200 1515715..1516653 + 939 WP_141017407.1 LysR family transcriptional regulator -
CJ010_RS07205 1516667..1517638 - 972 WP_141020605.1 prolyl aminopeptidase -
CJ010_RS07210 1517653..1519008 - 1356 WP_205754969.1 HipA domain-containing protein Toxin
CJ010_RS07215 1519013..1519273 - 261 WP_141017409.1 helix-turn-helix domain-containing protein Antitoxin
CJ010_RS07220 1519599..1519673 + 75 WP_083831988.1 pyrroloquinoline quinone precursor peptide PqqA -
CJ010_RS07225 1519732..1520646 + 915 WP_141017410.1 pyrroloquinoline quinone biosynthesis protein PqqB -
CJ010_RS07230 1520682..1521473 + 792 WP_205754909.1 pyrroloquinoline-quinone synthase PqqC -
CJ010_RS07235 1521470..1521760 + 291 WP_141017411.1 pyrroloquinoline quinone biosynthesis peptide chaperone PqqD -
CJ010_RS07240 1521763..1522944 + 1182 WP_141017412.1 pyrroloquinoline quinone biosynthesis protein PqqE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 452 a.a.        Molecular weight: 49679.78 Da        Isoelectric Point: 6.8210

>T80250 WP_205754969.1 NZ_CP022958:c1519008-1517653 [Azoarcus sp. DD4]
VGRRSHTRALGLWMNGAFVGTWSVTPHSGEILQYADDWVATEQGRPLSLSLPFTPGNRPHRGDAVRAYFENLLPDSKEIR
ERVARRFHAGSTDAFSLLTEIGRDCVGALQILPDGVVPAGVQAVEATPLSDAEVAQLLRNTVAQPPLGGADRADDDALRI
SIAGAQEKTALLWFDGNWCRPHGATPSTHIFKLPLGLVGNMQLDLRESVENEWLCSEILAAYGLPVARTQPLQFEDMKVL
AVERFDRMWWTSADGKRWLIRLPQEDMCQATATPPHLKYESDGGPGAGRIMDLLATSREAERDRRMFFQAQVIFWMLWAP
DGHAKNFSLFLRPGGAYELTPLYDVLSTSPMLGEGPGKLSPFKVKMAMAVRSKNAHWRMHDILRRHWVAVGQRHGIVTPD
GRGAECVVDDLVARTPAVVHAVRGKLPDGFPQVLADNILDSLLAAADKLAG

Download         Length: 1356 bp

>T80250 NZ_CP022958:c1519008-1517653 [Azoarcus sp. DD4]
GTGGGCCGACGTTCTCACACACGGGCCCTGGGCCTCTGGATGAATGGCGCCTTCGTGGGCACATGGAGCGTGACGCCCCA
CTCCGGCGAAATCCTGCAGTACGCCGATGACTGGGTGGCCACCGAGCAAGGGCGGCCGCTGTCGCTGTCCCTTCCCTTCA
CACCAGGCAATCGCCCTCATCGCGGCGACGCTGTGCGCGCCTACTTCGAGAACCTGCTACCGGACAGCAAGGAGATCCGC
GAGCGTGTCGCGCGCCGCTTCCACGCCGGCTCGACCGATGCGTTCTCCCTGCTGACCGAGATTGGCCGGGATTGCGTTGG
CGCCCTGCAGATACTGCCTGACGGAGTGGTTCCGGCCGGCGTGCAGGCGGTGGAGGCAACGCCGCTGAGCGACGCAGAGG
TGGCGCAGCTGCTGCGCAACACCGTGGCGCAACCACCGTTGGGCGGCGCGGATCGGGCCGACGACGATGCCTTGCGGATT
TCCATTGCCGGCGCACAGGAAAAGACTGCCCTGCTGTGGTTCGACGGCAACTGGTGCCGGCCACATGGCGCGACGCCATC
CACCCACATCTTCAAGCTGCCGTTGGGCCTGGTCGGCAACATGCAGCTCGACCTGCGCGAGTCGGTCGAAAACGAGTGGC
TGTGCTCGGAGATTCTGGCCGCCTATGGCTTGCCCGTGGCGCGCACCCAGCCCTTGCAGTTCGAGGACATGAAGGTGTTG
GCGGTCGAGCGATTCGACCGGATGTGGTGGACGTCTGCCGACGGGAAGCGCTGGCTCATCCGGTTGCCGCAGGAAGACAT
GTGCCAGGCCACCGCCACGCCGCCTCATCTCAAGTACGAATCCGACGGTGGGCCCGGCGCGGGTCGCATCATGGACTTGC
TGGCGACCTCCCGCGAGGCGGAGCGCGACCGACGCATGTTCTTCCAGGCCCAGGTAATCTTCTGGATGCTGTGGGCTCCC
GATGGTCACGCGAAGAACTTCAGTCTGTTCCTGCGTCCCGGGGGCGCCTACGAACTCACGCCGCTCTACGACGTGCTCTC
GACCTCTCCGATGCTCGGCGAAGGCCCCGGCAAGCTGTCGCCCTTCAAGGTGAAGATGGCCATGGCCGTGCGCTCAAAGA
ACGCGCACTGGCGTATGCACGACATCCTGCGCCGGCACTGGGTGGCTGTCGGTCAGCGCCATGGGATTGTGACGCCCGAC
GGCCGCGGGGCGGAATGCGTTGTCGATGACCTGGTCGCCCGTACACCAGCGGTTGTGCACGCAGTCCGTGGCAAACTGCC
GGACGGCTTCCCCCAAGTGCTGGCCGACAACATCCTGGACAGTCTGCTAGCCGCGGCCGACAAACTTGCCGGTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9159.54 Da        Isoelectric Point: 10.7159

>AT80250 WP_141017409.1 NZ_CP022958:c1519273-1519013 [Azoarcus sp. DD4]
MPDFTVRTAEQLPALLQGFRKQAGLTQAATAMRLGVTQQTLSALERNAEKVSAARLLQLLSILDVELVLRQGGATPTSGT
PSGPNW

Download         Length: 261 bp

>AT80250 NZ_CP022958:c1519273-1519013 [Azoarcus sp. DD4]
ATGCCCGACTTCACCGTTCGCACCGCAGAGCAGCTTCCCGCACTGCTTCAGGGGTTCCGCAAGCAGGCCGGCTTGACCCA
GGCAGCTACGGCGATGCGCCTGGGGGTGACCCAGCAGACGCTCTCCGCGCTGGAGCGCAATGCCGAGAAGGTCAGTGCCG
CCCGTTTACTGCAGCTGCTGAGCATCCTGGATGTCGAGCTCGTTCTGCGCCAGGGCGGCGCCACGCCGACGAGTGGCACG
CCATCCGGCCCGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References