Detailed information of TA system TA080094

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1625696..1626275
• Replicon: chromosome
• Accession: NZ_CP022908
• Organism: Staphylococcus aureus strain 545

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CGQ00_RS08420
• Protein ID: WP_001025401.1
• Coordinates: 1626030..1626275 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1625696..1626061 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGQ00_RS08380	1622439..1622996	-	558	WP_000645045.1	DUF2815 family protein	-
CGQ00_RS08385	1623022..1624188	-	1167	WP_115276638.1	DUF2800 domain-containing protein	-
CGQ00_RS08390	1624185..1624547	-	363	WP_031857745.1	hypothetical protein	-
CGQ00_RS08395	1624562..1624885	-	324	WP_000174994.1	hypothetical protein	-
CGQ00_RS08400	1624964..1625125	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CGQ00_RS08405	1625138..1625401	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CGQ00_RS08410	1625426..1625641	-	216	WP_031867168.1	hypothetical protein	-
CGQ00_RS08415	1625696..1626061	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CGQ00_RS08420	1626030..1626275	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CGQ00_RS08425	1626325..1626543	-	219	WP_001001383.1	hypothetical protein	-
CGQ00_RS08430	1626559..1627335	-	777	WP_001148559.1	phage antirepressor	-
CGQ00_RS08435	1627361..1627588	-	228	WP_001030311.1	hypothetical protein	-
CGQ00_RS08440	1627760..1628374	+	615	WP_000801423.1	XRE family transcriptional regulator	-
CGQ00_RS08445	1628390..1629310	+	921	WP_000348133.1	3'-5' exoribonuclease	-
CGQ00_RS08450	1629407..1629589	+	183	WP_000705240.1	hypothetical protein	-
CGQ00_RS08455	1629626..1629772	+	147	WP_072433242.1	hypothetical protein	-
CGQ00_RS08460	1629769..1630383	-	615	WP_000191463.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1585051..1649345	64294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T80094 WP_001025401.1 NZ_CP022908:c1626275-1626030 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T80094 NZ_CP022908:c1626275-1626030 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT80094 NZ_CP022908:1625696-1626061 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin