Detailed information of TA system TA080007

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1581958..1582537
• Replicon: chromosome
• Accession: NZ_CP022902
• Organism: Staphylococcus aureus strain 165

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CGP98_RS08080
• Protein ID: WP_001025401.1
• Coordinates: 1582292..1582537 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1581958..1582323 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CGP98_RS08040	1578701..1579258	-	558	WP_000645045.1	DUF2815 family protein	-
CGP98_RS08045	1579284..1580450	-	1167	WP_115276638.1	DUF2800 domain-containing protein	-
CGP98_RS08050	1580447..1580809	-	363	WP_031857745.1	hypothetical protein	-
CGP98_RS08055	1580824..1581147	-	324	WP_000174994.1	hypothetical protein	-
CGP98_RS08060	1581226..1581387	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CGP98_RS08065	1581400..1581663	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CGP98_RS08070	1581688..1581903	-	216	WP_031867168.1	hypothetical protein	-
CGP98_RS08075	1581958..1582323	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CGP98_RS08080	1582292..1582537	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CGP98_RS08085	1582587..1582805	-	219	WP_001001383.1	hypothetical protein	-
CGP98_RS08090	1582821..1583597	-	777	WP_001148559.1	phage antirepressor	-
CGP98_RS08095	1583623..1583850	-	228	WP_001030311.1	hypothetical protein	-
CGP98_RS08100	1584022..1584636	+	615	WP_000801423.1	XRE family transcriptional regulator	-
CGP98_RS08105	1584652..1585572	+	921	WP_000348133.1	3'-5' exoribonuclease	-
CGP98_RS08110	1585669..1585851	+	183	WP_000705240.1	hypothetical protein	-
CGP98_RS08115	1585888..1586034	+	147	WP_072433242.1	hypothetical protein	-
CGP98_RS08120	1586031..1586645	-	615	WP_000191463.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541313..1600732	59419

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T80007 WP_001025401.1 NZ_CP022902:c1582537-1582292 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T80007 NZ_CP022902:c1582537-1582292 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT80007 NZ_CP022902:1581958-1582323 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin